J
Jie Jia
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 31
Citations - 2109
Jie Jia is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Transfer RNA & EPRS. The author has an hindex of 18, co-authored 29 publications receiving 1844 citations. Previous affiliations of Jie Jia include Cleveland Clinic & Laboratory of Molecular Biology.
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Inhibition of genes expression of SARS coronavirus by synthetic small interfering RNAs.
TL;DR: SiRNA is capable of inhibiting SARS coronavirus genes expression and thus may be a new therapeutic strategy for treatment of SARS, and results suggest that many inactive siRNA duplexes may be brought to life simply by unpairing the 5' end of the antisense strands.
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A stress-responsive RNA switch regulates VEGFA expression.
TL;DR: An RNA switch in human vascular endothelial growth factor-A (VEGFA) mRNA 3′ untranslated region (UTR) that integrates signals from interferon (IFN)-γ and hypoxia to regulate VEGFA translation in myeloid cells is reported.
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The GAIT system: a gatekeeper of inflammatory gene expression
TL;DR: Repression of a post-transcriptional regulon by the GAIT system might contribute to the resolution of chronic inflammation.
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Target-selective protein S-nitrosylation by sequence motif recognition
TL;DR: Results reveal an elusive parallel between protein S-nitrosylation and phosphorylation, namely, stimulus-dependent posttranslational modification of selected targets by primary sequence motif recognition.
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WHEP domains direct noncanonical function of glutamyl-Prolyl tRNA synthetase in translational control of gene expression
TL;DR: Total reconstitution from purified components indicates that the four GAIT proteins are necessary and sufficient for self-assembly of a functional complex and establishes the essentiality of WHEP domains in the noncanonical function of EPRS in regulating inflammatory gene expression.