The GAIT system: a gatekeeper of inflammatory gene expression
TLDR
Repression of a post-transcriptional regulon by the GAIT system might contribute to the resolution of chronic inflammation.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2009-07-01 and is currently open access. It has received 229 citations till now. The article focuses on the topics: GAIT complex & EPRS.read more
Citations
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A guide to immunometabolism for immunologists
TL;DR: A brief refresher course on six of the major metabolic pathways involved in immunometabolism is provided, giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response.
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Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang,Jonathan D. Curtis,Leonard B. Maggi,Brandon Faubert,Alejandro V. Villarino,David O’Sullivan,Stanley Ching-Cheng Huang,Gerritje J.W. van der Windt,Julianna Blagih,Jing Qiu,Jason D. Weber,Edward J. Pearce,Russell G. Jones,Erika L. Pearce +13 more
TL;DR: It is shown here that aerobic glycolysis is specifically required for effector function in T cells but that this pathway is not necessary for proliferation or survival.
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RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts
Sarah Geisler,Jeff Coller +1 more
TL;DR: A paradigm in which lncRNAs regulate transcription via chromatin modulation is supported, but new functions are steadily emerging, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
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Macrophage death and defective inflammation resolution in atherosclerosis.
TL;DR: This Review provides an overview of concepts, with a focus on macrophage death and defective apoptotic cell clearance, and discusses new therapeutic strategies designed to boost inflammation resolution in atherosclerosis.
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Differential roles of microglia and monocytes in the inflamed central nervous system.
Ryo Yamasaki,Haiyan Lu,Oleg Butovsky,Nobuhiko Ohno,Anna Rietsch,Ron Cialic,Pauline M. Wu,Camille Doykan,Jessica Lin,Anne C. Cotleur,Grahame J. Kidd,Musab M. Zorlu,Nathan Sun,Weiwei Hu,LiPing Liu,Jar Chi Lee,Sarah E. Taylor,Lindsey Uehlein,Lindsey Uehlein,Debra Dixon,Jinyu Gu,Crina M. Floruta,Min Zhu,Israel F. Charo,Howard L. Weiner,Richard M. Ransohoff +25 more
TL;DR: Phagocytic monocyte-derived macrophages associate with the nodes of Ranvier and initiate demyelination while microglia clear debris and display a suppressed metabolic gene signature in EAE.
References
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Network Motifs: Simple Building Blocks of Complex Networks
TL;DR: Network motifs, patterns of interconnections occurring in complex networks at numbers that are significantly higher than those in randomized networks, are defined and may define universal classes of networks.
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The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
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