Jiesheng Li

TL;DR: In this article, the authors applied single-cell RNA sequencing to 284 samples from 196 COVID-19 patients and controls and created a comprehensive immune landscape with 1.46 million cells.

TL;DR: This study dissects the coordinated immune responses for different HBV infection phases and provides a rich resource for fully understanding immunopathogenesis and developing effective therapeutic strategies.

TL;DR: A computational method named IDEA (Isoform Detection, Enrichment, and functional Annotation) is proposed to comprehensively detect and annotate differentially used isoforms across cell subtypes to shed new light on the regulatory mechanisms of tumor-infiltrating T cells.

TL;DR: Lymphopenia and active T and B cell responses coexist and are shaped by age and sex SARS-CoV-2 infects diverse epithelial and immune cells, inducing distinct responses Cytokine storms with systemic S100A8/A9 are associated with COVID-19 severity.

TL;DR: A computational method named as IDEA is proposed to comprehensively detect and annotate differentially used isoforms across cell subtypes and sheds new lights into the regulatory mechanisms of tumor-infiltrating T cells.