J
Jimmy Larsson
Researcher at Uppsala University
Publications - 20
Citations - 741
Jimmy Larsson is an academic researcher from Uppsala University. The author has contributed to research in topics: Endothelial stem cell & Neural stem cell. The author has an hindex of 10, co-authored 18 publications receiving 595 citations. Previous affiliations of Jimmy Larsson include Science for Life Laboratory & Swedish University of Agricultural Sciences.
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Journal ArticleDOI
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
Konstantin Gaengel,Colin Niaudet,Kazuhiro Hagikura,Bàrbara Laviña,Lars Muhl,Jennifer J. Hofmann,Lwaki Ebarasi,Staffan Nyström,Simin Rymo,Simin Rymo,Long Long Chen,Mei-Fong Pang,Yi Jin,Elisabeth Raschperger,Pernilla Roswall,Dörte Schulte,Rui Benedito,Jimmy Larsson,Mats Hellström,Jonas Fuxe,Per Uhlén,Ralf H. Adams,Lars Jakobsson,Arindam Majumdar,Dietmar Vestweber,Anne Uv,Christer Betsholtz +26 more
TL;DR: It is shown that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability, and suggested that it acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.
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Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation
Anders R. Hellström,Brenda Watt,Shahrzad Shirazi Fard,Danièle Tenza,Paula Mannström,Kristina Narfström,Björn Ekesten,Shosuke Ito,Kazumasa Wakamatsu,Jimmy Larsson,Mats Ulfendahl,Klas Kullander,Graça Raposo,Susanne Kerje,Finn Hallböök,Michael S. Marks,Leif Andersson,Leif Andersson +17 more
TL;DR: Despite a mild effect on visible pigmentation, inactivation of Pmel led to a substantial reduction in eumelanin content in hair, which demonstrates that PMEL has a critical role for maintaining efficient epidermal pigmentation.
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Stem cell factor is a chemoattractant and a survival factor for CNS stem cells
TL;DR: Results show that SCF-induced chemotaxis and that specific antibodies to SCF or tyrosine kinase inhibitors abolished the migratory response, and suggest a role for SCF in cell migration and survival in the developing cortex.
Journal ArticleDOI
Time-resolved imaging-based CRISPRi screening
Daniel Camsund,Michael J. Lawson,Michael J. Lawson,Jimmy Larsson,Daniel Jones,Spartak Zikrin,David Fange,Johan Elf +7 more
TL;DR: DuMPLING (dynamic μ-fluidic microscopy phenotyping of a library before in situ genotyping) enables screening of dynamic phenotypes in strain libraries and was used here to study genes that coordinate replication and cell division in Escherichia coli.
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In situ genotyping of a pooled strain library after characterizing complex phenotypes
TL;DR: A proof‐of‐principle experiment that extends advanced live cell microscopy to the scale of pool‐generated strain libraries by identifying the genotypes for individual cells in situ after a detailed characterization of the phenotype.