B
Bàrbara Laviña
Researcher at Uppsala University
Publications - 28
Citations - 2105
Bàrbara Laviña is an academic researcher from Uppsala University. The author has contributed to research in topics: Chemistry & Angiogenesis. The author has an hindex of 11, co-authored 17 publications receiving 1309 citations. Previous affiliations of Bàrbara Laviña include Science for Life Laboratory & Karolinska Institutet.
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Journal ArticleDOI
A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.
Journal ArticleDOI
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
Konstantin Gaengel,Colin Niaudet,Kazuhiro Hagikura,Bàrbara Laviña,Lars Muhl,Jennifer J. Hofmann,Lwaki Ebarasi,Staffan Nyström,Simin Rymo,Simin Rymo,Long Long Chen,Mei-Fong Pang,Yi Jin,Elisabeth Raschperger,Pernilla Roswall,Dörte Schulte,Rui Benedito,Jimmy Larsson,Mats Hellström,Jonas Fuxe,Per Uhlén,Ralf H. Adams,Lars Jakobsson,Arindam Majumdar,Dietmar Vestweber,Anne Uv,Christer Betsholtz +26 more
TL;DR: It is shown that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability, and suggested that it acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.
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Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.
Liqun He,Michael Vanlandewijck,Michael Vanlandewijck,Maarja Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Åsa Segerstolpe,Jianping Liu,Sonja Gustafsson,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +23 more
TL;DR: The dataset constitutes a comprehensive molecular atlas of vascular and vessel-associated cell types in the mouse brain and lung, and as such provides a strong foundation for future studies of vascular development and diseases.
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Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss
Maarja Andaloussi Mäe,Liqun He,Liqun He,Sofia Nordling,Sofia Nordling,Elisa Vazquez-Liebanas,Khayrun Nahar,Bongnam Jung,Xidan Li,Bryan C. Tan,Juat Chin Foo,Amaury Cazenave-Gassiot,Markus R. Wenk,Yvette Zarb,Bàrbara Laviña,Susan E. Quaggin,Marie Jeansson,Marie Jeansson,Chengua Gu,David L. Silver,Michael Vanlandewijck,Michael Vanlandewijck,Eugene C. Butcher,Annika Keller,Christer Betsholtz,Christer Betsholtz +25 more
TL;DR: In this article, pericytes are described as capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair, and loss of pericyte has been described in several brain d...
Journal ArticleDOI
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.
Bàrbara Laviña,Marco Castro,Colin Niaudet,Bert Cruys,Alberto Álvarez-Aznar,Peter Carmeliet,Katie Bentley,Katie Bentley,Cord Brakebusch,Christer Betsholtz,Christer Betsholtz,Konstantin Gaengel +11 more
TL;DR: In this paper, the authors investigated the endothelial functions regulated by Cdc42 and their in vivo relevance during angiogenic sprouting and vascular morphogenesis in the postnatal mouse retina.