Staffan Nyström

TL;DR: It is shown that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability, and suggested that it acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.

TL;DR: These results cumulatively validate that Amot and AmotL1 have similar effects on endothelial migration and tight junction formation in vitro, however, in vivo Amot appears to control the polarity of vascular tip cells whereas Amot l1 mainly affects the stability of cell–cell junctions of the stalk cells.

TL;DR: Analysis of the expression of the two Amot isoforms during retinal angiogenesis in vivo shows that p80-Amot is expressed during the migratory phase and that homo-oligomerization of p80 and p130 are critical for this regulation.

TL;DR: The essential role of a single cysteine in the protein sirtuin 1 by the vertebrate-specific oxidoreductase glutaredoxin 2 is demonstrated for vessel formation and guidance during cardiovascular development, and results link S-glutathionylation to vertebrate development and successful embryonic angiogenesis.