J
Jin Seok Ahn
Researcher at Samsung Medical Center
Publications - 434
Citations - 13435
Jin Seok Ahn is an academic researcher from Samsung Medical Center. The author has contributed to research in topics: Lung cancer & Breast cancer. The author has an hindex of 53, co-authored 378 publications receiving 10368 citations. Previous affiliations of Jin Seok Ahn include Sungkyunkwan University.
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Journal ArticleDOI
First-SIGNAL: First-Line Single-Agent Iressa Versus Gemcitabine and Cisplatin Trial in Never-Smokers With Adenocarcinoma of the Lung
Ji-Youn Han,Keunchil Park,Sang-We Kim,Daeho Lee,Hyae Young Kim,Heung Tae Kim,Myung-Ju Ahn,Tak Yun,Jin Seok Ahn,Cheolwon Suh,Jung-Shin Lee,Sung Jin Yoon,Jong Hee Han,Jae Won Lee,Sook Jung Jo,Jin Soo Lee +15 more
TL;DR: Gefitinib failed to demonstrate superior OS compared with GP as first-line therapy for NSLAs in chemotherapy-naive N SLAs in Korean never-smokers.
Journal ArticleDOI
Alectinib in Crizotinib-Refractory ALK-Rearranged Non-Small-Cell Lung Cancer: A Phase II Global Study
Sai-Hong Ignatius Ou,Jin Seok Ahn,Luigi De Petris,Ramaswamy Govindan,James Chih-Hsin Yang,Brett G.M. Hughes,Hervé Lena,Denis Moro-Sibilot,Alessandra Bearz,Santiago Viteri Ramirez,Tarek Mekhail,Alexander I. Spira,Walter Bordogna,Bogdana Balas,Peter N. Morcos,Annabelle Monnet,Ali Zeaiter,Dong Wan Kim +17 more
TL;DR: Alectinib is highly active and well tolerated in patients with advanced, crizotinib-refractory ALK-positive NSCLC, including those with CNS metastases, and the cumulative CNS progression rate was lower than the cumulative non-CNS progression rate at 12 months for all patients.
Journal ArticleDOI
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.
Nayoung K.D. Kim,Nayoung K.D. Kim,Nayoung K.D. Kim,Hong Kwan Kim,Kyungjong Lee,Yourae Hong,Yourae Hong,Jong Ho Cho,Jung Won Choi,Jung-Il Lee,Yeon-Lim Suh,Bo Mi Ku,Hye Hyeon Eum,Hye Hyeon Eum,Hye Hyeon Eum,Soyean Choi,Yoon-La Choi,Yoon-La Choi,Je-Gun Joung,Woong-Yang Park,Woong-Yang Park,Hyun Ae Jung,Jong-Mu Sun,Se-Hoon Lee,Jin Seok Ahn,Keunchil Park,Myung-Ju Ahn,Hae-Ock Lee +27 more
TL;DR: The authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics to improve understanding of molecular and cellular dynamics in metastatic lung cancer.
Journal ArticleDOI
The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma
Sarah Park,Jeeyun Lee,Young Hyeh Ko,Arum Han,Hyun Jung Jun,Sang Chul Lee,In Gyu Hwang,Yeon Hee Park,Jin Seok Ahn,Chul Won Jung,Ki-Hyun Kim,Yong Chan Ahn,Won Ki Kang,Keunchil Park,Won Seog Kim +14 more
TL;DR: Takeaway is that DLBCL patients with EBER in situ hybridization+ pursued more rapidly deteriorating clinical course with poorer treatment response, survival, and progression-free survival.
Journal ArticleDOI
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
Hyunchul Jung,Hong Sook Kim,Jeong Yeon Kim,Jong-Mu Sun,Jin Seok Ahn,Myung-Ju Ahn,Keunchil Park,Manel Esteller,Se-Hoon Lee,Se-Hoon Lee,Jung Kyoon Choi +10 more
TL;DR: The authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.