Jin Wang

TL;DR: It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases.

TL;DR: The results indicate that Solexa sequencing allows the successful discovery of novel miRNAs from amphioxus with high accuracy and efficiency and provides an opportunity to decipher how the elaboration of the miRNA repertoire that occurred during chordate evolution contributed to the evolution of the vertebrate body plan.

TL;DR: The reciprocity of the interactions demonstrates that the coactivator complex could in principle be nucleated with either TFIID or mediator, implying that alternative pathways could be utilized to generate diversity in the way activators function in vivo.

TL;DR: It is shown that hypoxia can stimulate the expression of PGC-1α and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocyte to increase ATP output and minimize hypoxic damage to the heart.

TL;DR: This work demonstrates how choice of pathway structure and centrality measurement, as well as the presence of key genes, affects pathway significance and benefits the systematic analysis of biological pathways and help to extract more meaningful information from gene expression data.