J
Jin Wang
Researcher at Nanjing University
Publications - 63
Citations - 5422
Jin Wang is an academic researcher from Nanjing University. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 18, co-authored 57 publications receiving 4974 citations. Previous affiliations of Jin Wang include Peking University & Nanjing Agricultural University.
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Journal ArticleDOI
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Xi Chen,Yi Ba,Lijia Ma,Lijia Ma,Xing Cai,Yuan Yin,Kehui Wang,Jigang Guo,Yujing Zhang,Jiangning Chen,Xing Guo,Qibin Li,Qibin Li,Xiaoying Li,Wenjing Wang,Yan Zhang,Jin Wang,Xueyuan Jiang,Yang Xiang,Chen Xu,Pingping Zheng,Juanbin Zhang,Ruiqiang Li,Hongjie Zhang,Xiaobin Shang,Ting Gong,Guang Ning,Jun Wang,Jun Wang,Ke Zen,Junfeng Zhang,Chen-Yu Zhang +31 more
TL;DR: It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases.
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Identification and characterization of novel amphioxus microRNAs by Solexa sequencing.
Xi Chen,Qibin Li,Qibin Li,Qibin Li,Jin Wang,Xing Guo,Xiangrui Jiang,Zhiji Ren,Chunyue Weng,Guoxun Sun,Xiuqiang Wang,Yaping Liu,Lijia Ma,Jun-Yuan Chen,Jun Wang,Ke Zen,Junfeng Zhang,Chen-Yu Zhang +17 more
TL;DR: The results indicate that Solexa sequencing allows the successful discovery of novel miRNAs from amphioxus with high accuracy and efficiency and provides an opportunity to decipher how the elaboration of the miRNA repertoire that occurred during chordate evolution contributed to the evolution of the vertebrate body plan.
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TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA
TL;DR: The reciprocity of the interactions demonstrates that the coactivator complex could in principle be nucleated with either TFIID or mediator, implying that alternative pathways could be utilized to generate diversity in the way activators function in vivo.
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Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients.
Lingyun Zhu,Qiang Wang,Lin Zhang,Zhixiang Fang,Fang Zhao,Zhiyuan Lv,Zuguang Gu,Junfeng Zhang,Jin Wang,Ke Zen,Yang Xiang,Dongjin Wang,Chen-Yu Zhang +12 more
TL;DR: It is shown that hypoxia can stimulate the expression of PGC-1α and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocyte to increase ATP output and minimize hypoxic damage to the heart.
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Centrality-based pathway enrichment: a systematic approach for finding significant pathways dominated by key genes
TL;DR: This work demonstrates how choice of pathway structure and centrality measurement, as well as the presence of key genes, affects pathway significance and benefits the systematic analysis of biological pathways and help to extract more meaningful information from gene expression data.