JingQi Huang

TL;DR: Caspases appear to play a dual role in proteolytic processing of APP and the resulting propensity for Aβ peptide formation, as well as in the ultimate apoptotic death of neurons in Alzheimer's disease.

TL;DR: Findings suggest that putative caspase-independent apoptosis may be overestimated in some systems since blockade of spectrin proteolysis and other cell death markers does not accurately reflect the high degrees of casp enzyme-3 inhibition needed to prevent DNA fragmentation.

TL;DR: It is concluded that the alpha-amanitin-resistant transcription of protein coding genes in T. brucei is not mediated by a diverged form of the largest subunit of pol II and that the presence of both the pol IIA and pol IIB genes is not essential for trypanosome viability.

TL;DR: The use of a novel radiolabeled caspase inhibitor, [125I]M808, and an active site occupancy assay, which measure the fractional inhibition required to block apoptosis-induced DNA fragmentation suggest that a high and persistent fractional inhibited will be required for successful caspases inhibition-based therapies.

TL;DR: In this paper, the roles of apoptotic proteases and caspases in cleavage of amyloid-β precursor protein (APP) and biogenesis of AMyloidogenic Aβ peptide species are described.