J
Jingshi Shen
Researcher at University of Colorado Boulder
Publications - 45
Citations - 4941
Jingshi Shen is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Lipid bilayer fusion & Vesicle fusion. The author has an hindex of 19, co-authored 40 publications receiving 4450 citations. Previous affiliations of Jingshi Shen include Allergan & Johns Hopkins University.
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Journal ArticleDOI
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals.
TL;DR: It is found that the ER chaperone BiP/GRP78 binds ATF6 and dissociates in response to ER stress and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi.
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Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response
TL;DR: A consensus DNA binding sequence is identified for ATF6, related to but distinct from ATF1/CREB binding sites, which was specifically activated by ATF6 overexpression and was strongly induced by the ER stress response.
Journal ArticleDOI
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
TL;DR: A fundamental role is demonstrated of the SM protein: to act as a stimulatory subunit of its cognate SNARE fusion machinery, enhancing fusion specificity in a reconstituted system.
Journal ArticleDOI
The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi
Xi Chen,Jingshi Shen,Ron Prywes +2 more
TL;DR: The results show that ATF6 has a mechanism to sense ER stress and respond by translocation to the Golgi and suggest that the conserved CD1 region is required for translocation, whereas the CD2 region is necessary for site 1 protease cleavage.
Journal ArticleDOI
Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1
Jingshi Shen,R Samul,Raquel Lima e Silva,Hideo Akiyama,Hongting Liu,Yoshitsugu Saishin,Sean F. Hackett,Shawn Zinnen,K Kossen,Kathy Fosnaugh,Chandra Vargeese,A. Gomez,K. Bouhana,R. Aitchison,Pamela Pavco,Peter A. Campochiaro +15 more
TL;DR: Data suggest that VEGFR1 plays an important role in the development of retinal and CNV and that targeting vegfr1 mRNA with siRNA has therapeutic potential.