J
Jinming Han
Researcher at Karolinska University Hospital
Publications - 46
Citations - 1008
Jinming Han is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Medicine & Microglia. The author has an hindex of 11, co-authored 32 publications receiving 561 citations. Previous affiliations of Jinming Han include Karolinska Institutet & Capital Medical University.
Papers
More filters
Journal ArticleDOI
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells.
Harald Lund,Melanie Pieber,Roham Parsa,Jinming Han,David Grommisch,Ewoud Ewing,Lara Kular,Maria Needhamsen,Alexander Espinosa,Emma Nilsson,Anna K. Överby,Oleg Butovsky,Maja Jagodic,Xing-Mei Zhang,Robert A. Harris +14 more
TL;DR: It is shown that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter having overlapping but distinct characteristics.
Journal ArticleDOI
An updated assessment of microglia depletion: current concepts and future directions.
TL;DR: The highly plastic and diverse phenotypes of microglia are highlighted and lessons learned from microglian depletion approaches are outlined, thus holding promise for designing strategies to resolve neuroinflammation and promote recovery.
Journal ArticleDOI
Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models.
TL;DR: The features of TFH cells, including their development, function, and roles as well as TFH-associated molecules in neuroautoimmune diseases and their animal models are summarized.
Journal ArticleDOI
Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders
TL;DR: Although glial cell replacement therapy is still in its infancy and future translational studies are still required, the approach is scientifically sound and provides new optimism for managing the neurotoxicity and neuroinflammation induced by activated microglia.
Journal ArticleDOI
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling.
Harald Lund,Melanie Pieber,Roham Parsa,David Grommisch,Ewoud Ewing,Lara Kular,Jinming Han,Keying Zhu,Jik Nijssen,Eva Hedlund,Maria Needhamsen,Sabrina Ruhrmann,André Ortlieb Guerreiro-Cacais,Rasmus Berglund,Maria J. Forteza,Daniel F. J. Ketelhuth,Oleg Butovsky,Maja Jagodic,Xing-Mei Zhang,Robert A. Harris +19 more
TL;DR: It is found that abrogation of TGF-β signaling in CX3CR1+ monocyte-derived macrophages led to rapid onset of a progressive and fatal demyelinating motor disease characterized by myelin-laden giantmacrophages throughout the spinal cord.