R
Robert A. Harris
Researcher at Karolinska Institutet
Publications - 181
Citations - 9190
Robert A. Harris is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Microglia. The author has an hindex of 47, co-authored 169 publications receiving 7789 citations. Previous affiliations of Robert A. Harris include University of London & Max Planck Society.
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Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells
TL;DR: It is demonstrated that T cells that are specific for different myelin epitopes generate populations characterized by different T helper type 17 (TH17) to T helpertype 1 (TH1) ratios depending on the functional avidity of interactions between TCR and peptide-MHC complexes.
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RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages.
R. Kokkola,Åsa Andersson,G. Mullins,Therese Östberg,Carl Johan Treutiger,B. Arnold,P. Nawroth,Ulf Andersson,Robert A. Harris,Helena Erlandsson Harris +9 more
TL;DR: HMGB1 has the potential to induce a proinflammatory phenotype in Mφ, with RAGE as the major activation‐inducing receptor.
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Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Anna-Maria Georgoudaki,Kajsa E. Prokopec,Vanessa F. Boura,Eva Hellqvist,Silke Sohn,Jeanette Östling,Rony Dahan,Robert A. Harris,Mattias Rantalainen,Daniel Klevebring,Malin Sund,Suzanne Egyhazi Brage,Jonas Fuxe,Charlotte Rolny,Fubin Li,Fubin Li,Jeffrey V. Ravetch,Mikael C. I. Karlsson +17 more
TL;DR: It is found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome, and it is demonstrated that immunotherapies using antibodies designed to modify myeloid cells of the TME represent a promising mode of cancer treatment.
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Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin
TL;DR: The findings suggest that decreased levels of insulin and increased levels of fatty acids and glucocorticoids promote PDK4 gene expression in starvation and diabetes.
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A Breakthrough: Macrophage-Directed Cancer Immunotherapy
TL;DR: That macrophages/innate immunity can be modulated to play a central role in directly or indirectly combating cancer is a breakthrough that seems likely to finally make successful immunotherapy of cancer a reality.