G
Graham M. West
Researcher at Pfizer
Publications - 37
Citations - 3103
Graham M. West is an academic researcher from Pfizer. The author has contributed to research in topics: Protein structure & Protein ligand. The author has an hindex of 19, co-authored 35 publications receiving 2577 citations. Previous affiliations of Graham M. West include United States Environmental Protection Agency & Scripps Research Institute.
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Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases
Fen Fen Soon,Fen Fen Soon,Ley Moy Ng,Ley Moy Ng,X. Edward Zhou,Graham M. West,Amanda Kovach,M. H. Eileen Tan,M. H. Eileen Tan,Kelly Suino-Powell,Yuanzheng He,Yong Xu,Michael J. Chalmers,Joseph S. Brunzelle,Huiming Zhang,Huaiyu Yang,Hualiang Jiang,Jun Li,Jun Li,Eu Leong Yong,Sean R. Cutler,Jian-Kang Zhu,Patrick R. Griffin,Karsten Melcher,H. Eric Xu,H. Eric Xu +25 more
TL;DR: Structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.
Journal ArticleDOI
HDX workbench: software for the analysis of H/D exchange MS data.
Bruce D. Pascal,Scooter Willis,Janelle L. Lauer,Rachelle R. Landgraf,Graham M. West,David Marciano,Scott J. Novick,Devrishi Goswami,Michael J. Chalmers,Patrick R. Griffin +9 more
TL;DR: An integrated desktop program titled HDX Workbench is reported, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets and validated data analysis can be achieved at the rate of generation.
Journal ArticleDOI
Delineating the role of cooperativity in the design of potent PROTACs for BTK
Adelajda Zorba,Chuong Nguyen,Yingrong Xu,Jeremy T. Starr,Kris A. Borzilleri,James F. Smith,Hongyao Zhu,Kathleen A. Farley,WeiDong Ding,James Schiemer,Xidong Feng,Jeanne S. Chang,Daniel P. Uccello,Jennifer A. Young,Carmen N. Garcia-Irrizary,Lara C. Czabaniuk,Brandon P. Schuff,Robert M. Oliver,Justin I. Montgomery,Matthew Merrill Hayward,Jotham Wadsworth Coe,Jinshan Chen,Mark Niosi,Suman Luthra,Jaymin C. Shah,Ayman El-Kattan,Xiayang Qiu,Graham M. West,Mark C. Noe,Veerabahu Shanmugasundaram,Adam M. Gilbert,Matthew Frank Brown,Matthew F. Calabrese +32 more
TL;DR: It is shown that within a Bruton’s tyrosine kinase/cereblon PROTAC system, potent knockdown correlates with alleviation of steric clashes in the absence of thermodynamic cooperativity, which broadens the scope of PROTAC applications and affects fundamental design criteria across the field.
Journal ArticleDOI
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions
TL;DR: How HDX analysis of protein–ligand interactions has had an impact on biology and drug discovery is summarized.