J
Jinze Xu
Researcher at University of Florida
Publications - 22
Citations - 2405
Jinze Xu is an academic researcher from University of Florida. The author has contributed to research in topics: Oxidative stress & Sarcopenia. The author has an hindex of 17, co-authored 22 publications receiving 2106 citations. Previous affiliations of Jinze Xu include Fudan University.
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Journal ArticleDOI
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
Shinichi Someya,Shinichi Someya,Wei Yu,William C. Hallows,Jinze Xu,James M. Vann,Christiaan Leeuwenburgh,Masaru Tanokura,John M. Denu,Tomas A. Prolla +9 more
TL;DR: These findings suggest that Sirt3-dependent mitochondrial adaptations may be a central mechanism of aging retardation in mammals and suggest that CR reduces oxidative DNA damage in multiple tissues and prevents AHL in wild-type mice but fails to modify these phenotypes in mice lacking the mitochondrial deacetylase Sirt 3.
Journal ArticleDOI
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis
Shinichi Someya,Jinze Xu,Kenji Kondo,Dalian Ding,Richard Salvi,Tatsuya Yamasoba,Peter S. Rabinovitch,Richard Weindruch,Christiaan Leeuwenburgh,Masaru Tanokura,Tomas A. Prolla +10 more
TL;DR: Induction of a Bak-dependent mitochondrial apoptosis program in response to oxidative stress is a key mechanism of AHL in C57BL/6J mice.
Journal ArticleDOI
Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity
TL;DR: It is proposed that rapamycin offers cytoprotection against oxidative stress by a combined approach of removing dysfunctional mitochondria as well as by degrading damaged, ubiquitinated proteins.
Journal ArticleDOI
Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy.
Tim Hofer,Emanuele Marzetti,Emanuele Marzetti,Jinze Xu,Arnold Y. Seo,Sukru Gulec,Mitchell D. Knutson,Christiaan Leeuwenburgh,Esther E. Dupont-Versteegden +8 more
TL;DR: Results suggest that RNA oxidation, possibly mediated by increased non-heme iron, might contribute to muscle atrophy due to disuse particularly in aged muscle.
Journal ArticleDOI
Mitochondrial iron accumulation with age and functional consequences
Arnold Y. Seo,Jinze Xu,Stephane Servais,Tim Hofer,Emanuele Marzetti,Emanuele Marzetti,Stephanie E. Wohlgemuth,Mitchell D. Knutson,Hae Young Chung,Christiaan Leeuwenburgh +9 more
TL;DR: The data suggest that age‐dependent accumulation of mitochondrial iron may increase mitochondrial dysfunction and oxidative damage, thereby enhancing the susceptibility to apoptosis.