R
R. Alan B. Ezekowitz
Researcher at Harvard University
Publications - 66
Citations - 8734
R. Alan B. Ezekowitz is an academic researcher from Harvard University. The author has contributed to research in topics: Mannan-binding lectin & Innate immune system. The author has an hindex of 44, co-authored 66 publications receiving 8323 citations. Previous affiliations of R. Alan B. Ezekowitz include Merck & Co. & Osaka University.
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Journal ArticleDOI
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.
TL;DR: It is demonstrated that PGRP-LC is an essential component for recognition and signalling of Gram-negative bacteria and is important for antibacterial peptide synthesis induced by Escherichia coli both in vitro and in vivo.
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The mannose receptor is a pattern recognition receptor involved in host defense.
TL;DR: The mannose receptor is the prototype of a new family of multilectin receptor proteins (membrane-spanning receptors containing eight-ten lectin-like domains, which appear to play a key role in host defense) and provides a link between innate and adaptive immunity.
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Phagocytosis: Elegant Complexity
TL;DR: How the challenge of recognizing diverse molecular patterns is met by combinatorial interactions between phagocytic receptors is discussed and an important role for genetically tractable model organisms is indicated in defining key components of this evolutionarily conserved process.
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Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
Lynda M. Stuart,Jiusheng Deng,Jessica M. Silver,Kazue Takahashi,Anita A. Tseng,Elizabeth J. Hennessy,R. Alan B. Ezekowitz,Kathryn J. Moore +7 more
TL;DR: In this article, the Drosophila melanogaster scavenger receptor Croquemort was identified as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria.
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Croquemort, A Novel Drosophila Hemocyte/Macrophage Receptor that Recognizes Apoptotic Cells
Nathalie C. Franc,Nathalie C. Franc,Jean-Luc Dimarcq,Jean-Luc Dimarcq,Marie Lagueux,Jules A. Hoffmann,R. Alan B. Ezekowitz +6 more
TL;DR: The findings support the idea that the primordial function of macrophages may have been in tissue modeling and that their adapted role is in host defense.