J
Jo Lynne Phinizy
Researcher at Texas A&M University System
Publications - 45
Citations - 2756
Jo Lynne Phinizy is an academic researcher from Texas A&M University System. The author has contributed to research in topics: Cholangiocyte & Cholangiocyte proliferation. The author has an hindex of 28, co-authored 45 publications receiving 2648 citations. Previous affiliations of Jo Lynne Phinizy include Scott & White Hospital & Temple University.
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Journal ArticleDOI
Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion☆☆☆
Gianfranco Alpini,Shannon Glaser,Yoshiyuki Ueno,Rebecca Rodgers,Jo Lynne Phinizy,Heather Francis,Leonardo Baiocchi,Leigh A. Holcomb,Alessandra Caligiuri,Gene LeSage +9 more
TL;DR: Data indicate that elevated BA levels stimulate ductal secretion and cholangiocyte proliferation, and is associated with de novo secretin-stimulated bile flow and bicarbonate secretion.
Journal ArticleDOI
Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes.
Gianfranco Alpini,Shannon Glaser,Rebecca Rodgers,Jo Lynne Phinizy,W. Robertson,John Lasater,Alessandra Caligiuri,Ziga Tretjak,Gene LeSage +8 more
TL;DR: These proteins may mediate bile acid uptake from the duct lumen in large ducts, resulting in modification of canalicular bile gland secretion and modulation of ductal bile secretion and growth.
Journal ArticleDOI
Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct–ligated rats
Gene LeSage,Domenico Alvaro,A. Benedetti,Shannon Glaser,Luca Marucci,Leonardo Baiocchi,Wendy Eisel,Alessandra Caligiuri,Jo Lynne Phinizy,Rebecca Rodgers,Heather Francis,Gianfranco Alpini +11 more
TL;DR: Investigation of the role of the cholinergic system in regulation of cholangiocyte functions in rats that underwent bile duct ligation found that maintenance of cAMP levels by forskolin administration prevents the effects of vagotomy on cholangoocyte proliferation, apoptosis, and secretion.
Journal ArticleDOI
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
Marco Marzioni,Shannon Glaser,Heather Francis,Luca Marucci,Antonio Benedetti,Domenico Alvaro,Silvia Taffetani,Yoshiyuki Ueno,Tania Roskams,Jo Lynne Phinizy,J Venter,Giammarco Fava,Gene LeSage,Gianfranco Alpini,Gianfranco Alpini +14 more
TL;DR: The existence of an autocrine loop based on serotonin that limits the growth of the biliary tree in the course of chronic cholestasis is observed and might open new approaches for the management of cholangiopathies.
Journal ArticleDOI
Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion
Gianfranco Alpini,Shannon Glaser,W. Robertson,Rebecca Rodgers,Jo Lynne Phinizy,John Lasater,Gene LeSage +6 more
TL;DR: It is proposed that agonist-induced ductal secretion occurs in large but not small intrahepatic bile duct units (IBDU), which are separated from large IBDU by morphometric analysis, gene expression, and secretion by change in luminal size in response to agonists.