Journal ArticleDOI
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
Marco Marzioni,Shannon Glaser,Heather Francis,Luca Marucci,Antonio Benedetti,Domenico Alvaro,Silvia Taffetani,Yoshiyuki Ueno,Tania Roskams,Jo Lynne Phinizy,J Venter,Giammarco Fava,Gene LeSage,Gianfranco Alpini,Gianfranco Alpini +14 more
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TLDR
The existence of an autocrine loop based on serotonin that limits the growth of the biliary tree in the course of chronic cholestasis is observed and might open new approaches for the management of cholangiopathies.About:
This article is published in Gastroenterology.The article was published on 2005-01-01. It has received 153 citations till now. The article focuses on the topics: Cholangiocyte proliferation & Protein kinase C signaling.read more
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Journal ArticleDOI
Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver.
Domenico Alvaro,Maria Grazia Mancino,Shannon Glaser,Eugenio Gaudio,Marco Marzioni,Heather Francis,Gianfranco Alpini +6 more
TL;DR: The purpose of this review is to summarize the recent findings on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangsiocyte biology.
Journal ArticleDOI
Effect of dietary fibre enrichment on selected properties of gluten-free bread.
TL;DR: In this article, different cereal fibres (wheat, maize, oat and barley) were added at 3, 6 and 9 grams/100 grams level into a gluten-free bread formulation based on corn starch, rice flour and hydroxypropyl methyl cellulose (HPMC).
SPECIAL REPORTS AND REVIEWS Proliferating Cholangiocytes: A Neuroendocrine Compartment in the Diseased Liver
Domenico Alvaro,Maria Grazia Mancino,Shannon Glaser,Eugenio Gaudio,Marco Marzioni,Heather Francis,Gianfranco Alpini +6 more
Journal ArticleDOI
Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches
Gideon M. Hirschfield,Gideon M. Hirschfield,E. Jenny Heathcote,E. Jenny Heathcote,M. Eric Gershwin +4 more
TL;DR: A greater understanding of the physiology of cholangiocytes at the cellular and molecular levels, as well as genetic factors, repair pathways, and autoimmunity mechanisms involved in the pathogenesis of disease are understood.
OtherDOI
Principles of Liver Regeneration and Growth Homeostasis
TL;DR: The complex challenges of the liver toward body homeostasis are always preserved by complex but unfailing responses involving orchestrated signaling and affecting growth and differentiation of all hepatic cell types.
References
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Journal ArticleDOI
HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY
Alexander M. Rutenburg,Hwakyu Kim,Jerome W. Fischbein,Jacob S. Hanker,Hannah L. Wasserkrug,Arnold M. Seligman +5 more
TL;DR: In this paper, a simultaneous coupling azo dye method for the histochemical demonstration of γ-glutamyl transpeptidase activity using the new substrate γglutamide-4methoxy-2-naphthylamide has been described.
Journal ArticleDOI
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
Journal ArticleDOI
Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis.
TL;DR: Serotonin regulates cell proliferation, migration and maturation in a variety of cell types, including lung, kidney, endothelial cells, mast cells, neurons and astrocytes and in humans, 5-HT2A receptor drugs produce hallucinations.
Journal ArticleDOI
Management of primary biliary cirrhosis
TL;DR: The hydrophilic bile acid, ursodeoxycholic acid (UDCA), has been shown when given in a dose of 13 to 15 mg/kg daily for up to 4 years to delay the time to liver transplantation or death and causes a significant improvement of all the biochemical markers of cholestasis but has no beneficial effects on any of the symptoms or associated disorders.
Journal ArticleDOI
Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.
TL;DR: These studies indicate that, in the rat, the proliferated bile ductules/ducts spontaneously secrete bile and are the site of secretin choleresis, a property of biliary epithelial cells.
Related Papers (5)
Vascular Endothelial Growth Factor Stimulates Rat Cholangiocyte Proliferation Via an Autocrine Mechanism
Eugenio Gaudio,Barbara Barbaro,Barbara Barbaro,Domenico Alvaro,Shannon Glaser,Heather Francis,Yoshiyuki Ueno,Cynthia J. Meininger,Antonio Franchitto,Paolo Onori,Marco Marzioni,Silvia Taffetani,Giammarco Fava,George Stoica,Julie Venter,Ramona Reichenbach,Sharon De Morrow,Ryun Summers,Gianfranco Alpini +18 more