J
Joanna Brunel
Researcher at University of Lyon
Publications - 12
Citations - 896
Joanna Brunel is an academic researcher from University of Lyon. The author has contributed to research in topics: DEAD Box Protein 58 & RNA. The author has an hindex of 8, co-authored 9 publications receiving 762 citations. Previous affiliations of Joanna Brunel include Claude Bernard University Lyon 1 & Lyon College.
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Journal ArticleDOI
Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA
Eva Kowalinski,Thomas Lunardi,Andrew A. McCarthy,Jade Louber,Joanna Brunel,Boyan Grigorov,Denis Gerlier,Stephen Cusack +7 more
TL;DR: It is proposed that after initial binding of 5'ppp-dsRNA to the flexibly linked CTD, co-operative tight binding of ATP and RNA to the helicase domain liberates the CARDs for downstream signaling.
Journal ArticleDOI
Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
TL;DR: It is proposed that LGP2 end-binding may promote nucleation of MDA5 oligomerization on dsRNA, causing interferon production in virus-derived short 5′ppp blunt-ended or long ds RNA.
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Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5
TL;DR: The exquisite fine-tuning of RIG-I and MDA5 RNA-dependent ATPase activity coupled to CARD release allows a robust IFN response from a minor subset of non-self RNAs within a sea of cellular self RNAs.
Journal ArticleDOI
Sequence of Events in Measles Virus Replication: Role of Phosphoprotein-Nucleocapsid Interactions
Joanna Brunel,Damien Chopy,Marion Dosnon,Louis Marie Bloyet,Patricia Devaux,Erica Urzua,Roberto Cattaneo,Sonia Longhi,Denis Gerlier +8 more
TL;DR: In this paper, the role of protein-protein interaction in polymerase function was further characterized, showing that an increase in PXD-toN TAILbinding strength is associated with a slower transcript accumulation rate and that abolishing the interaction renders the polymerase nonfunctional.
Journal ArticleDOI
Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by PXD to NTAIL Binding Strength.
Louis Marie Bloyet,Joanna Brunel,Marion Dosnon,Marion Dosnon,Véronique Hamon,Véronique Hamon,Véronique Hamon,Jenny Erales,Jenny Erales,Antoine Gruet,Antoine Gruet,Carine Lazert,Christophe Bignon,Christophe Bignon,Philippe Roche,Philippe Roche,Philippe Roche,Sonia Longhi,Sonia Longhi,Denis Gerlier +19 more
TL;DR: A key role is explored here to which extent the binding of the X domain of P to the C-terminal region of the N protein (NTAIL) is involved in maintaining the P/L complex anchored to the nucleocapsid template during the sequential transcription of measles virus genes.