Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA
Eva Kowalinski,Thomas Lunardi,Andrew A. McCarthy,Jade Louber,Joanna Brunel,Boyan Grigorov,Denis Gerlier,Stephen Cusack +7 more
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It is proposed that after initial binding of 5'ppp-dsRNA to the flexibly linked CTD, co-operative tight binding of ATP and RNA to the helicase domain liberates the CARDs for downstream signaling.About:
This article is published in Cell.The article was published on 2011-10-14 and is currently open access. It has received 565 citations till now. The article focuses on the topics: LGP2 & RNA Helicase A.read more
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Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
Jiaxi Wu,Zhijian J. Chen +1 more
TL;DR: Recent advances in understanding the mechanism of nucleic acid sensing and signaling in the cytosol of mammalian cells as well as the emerging role of cytosolic nucleic acids in autoimmunity are reviewed.
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Molecular Mechanisms of RNA Interference
TL;DR: Molecular structures of Dicer and Argonaute proteins, and of RNA-bound complexes, have offered exciting insights into the mechanisms operating at the heart ofRNA-silencing pathways.
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Innate immunity to influenza virus infection.
Akiko Iwasaki,Padmini S. Pillai +1 more
TL;DR: Whether the outcome of innate sensor stimulation promotes antiviral resistance or disease tolerance, and proposed rational treatment strategies for the acute respiratory disease that is caused by influenza virus infection are considered.
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Cytosolic Sensing of Viruses
TL;DR: Recent advances in the molecular understanding of cytosolic nucleic acid detection and its evasion by viruses are detailed.
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Immune sensing of DNA
Søren R. Paludan,Andrew G. Bowie +1 more
TL;DR: Progress is described in understanding signaling mechanisms activated by DNA and the relevance of DNA sensing to pathogen responses and autoimmunity and new insights are highlighted into how and why the immune system responds to both pathogen and self DNA.
References
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UCSF Chimera--a visualization system for exploratory research and analysis.
Eric F. Pettersen,Thomas D. Goddard,Conrad C. Huang,Gregory S. Couch,Daniel M. Greenblatt,Elaine C. Meng,Thomas E. Ferrin +6 more
TL;DR: Two unusual extensions are presented: Multiscale, which adds the ability to visualize large‐scale molecular assemblies such as viral coats, and Collaboratory, which allows researchers to share a Chimera session interactively despite being at separate locales.
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Coot: model-building tools for molecular graphics.
Paul Emsley,Kevin Cowtan +1 more
TL;DR: CCP4mg is a project that aims to provide a general-purpose tool for structural biologists, providing tools for X-ray structure solution, structure comparison and analysis, and publication-quality graphics.
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Phaser crystallographic software
Airlie J. McCoy,Ralf W. Grosse-Kunstleve,Paul D. Adams,Martyn Winn,Laurent C. Storoni,Randy J. Read +5 more
TL;DR: A description is given of Phaser-2.1: software for phasing macromolecular crystal structures by molecular replacement and single-wavelength anomalous dispersion phasing.
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Refinement of macromolecular structures by the maximum-likelihood method.
TL;DR: The likelihood function for macromolecular structures is extended to include prior phase information and experimental standard uncertainties and the results derived are consistently better than those obtained from least-squares refinement.
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MolProbity: all-atom structure validation for macromolecular crystallography
Vincent B. Chen,W. Bryan Arendall,Jeffrey J. Headd,Daniel A. Keedy,R.M. Immormino,Gary J. Kapral,Laura Weston Murray,Jane S. Richardson,David S. Richardson +8 more
TL;DR: MolProbity structure validation will diagnose most local errors in macromolecular crystal structures and help to guide their correction.