J
Joanne E. Martin
Researcher at Queen Mary University of London
Publications - 130
Citations - 8938
Joanne E. Martin is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Myopathy. The author has an hindex of 39, co-authored 130 publications receiving 8428 citations. Previous affiliations of Joanne E. Martin include Royal London Hospital & University of Oxford.
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Purkinje cell toxicity of β-aminopropionitrile in the rat
TL;DR: High-dose intraperitoneal BAPN in the rat causes Purkinje cell changes, but no other central nervous system abnormalities, and Immunohistochemical studies of phosphorylated neurofilaments and the 72 kDa heat shock protein were normal and no intraneuronal ubiquitinated inclusions were seen.
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Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.
Majid Hafezparast,Sebastian Brandner,Jackie Linehan,Joanne E. Martin,John Collinge,Elizabeth M. C. Fisher +5 more
TL;DR: To investigate the role of cytoplasmic dynein in the transmission of prions within neurons, inoculated heterozygous Loa and wild type littermates with mouse-adapted scrapie prions intracerebrally and intraperitonially and determined the incubation period to onset of clinical prion disease.
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New insights in motor neuron disease.
TL;DR: New information is reviewed on the clinical, toxicological and pathological features of the motor neuron disease, including accumulations of previously unrecognized ubiquitinated material described in surviving neurons, which cannot be demonstrated with routine histological methods.
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Development of fetal haemoglobin-blood cells (F cells) within colorectal tumour tissues
TL;DR: The apparent development of FRBCs in colorectal tumours is an interesting observation, as these cells were previously thought to develop in medullary or lymphoid tissues, and it is suggested that the colonic microenvironment may stimulate extramedullary fetal-type haematopoiesis.
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The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles
D. D. Ateh,Veronica H. L. Leinster,Sally R. Lambert,Afsha Shah,Ayub Khan,Hazel J. Walklin,Jennifer V. Johnstone,Nader I. Ibrahim,Mustafa M. Kadam,Zain Malik,Míriam Gironès,Gert J. Veldhuis,Gary Warnes,Silvia Marino,Iain A. McNeish,Joanne E. Martin +15 more
TL;DR: It is shown that CD95 surface modification of relatively large microparticles >0.5 μm in diameter, including those made from biodegradable polylactic-co-glycolic acid (PLGA), enhances intracellular uptake by a range of CD95L expressing cells in a process akin to phagocytosis.