Joanne E. Martin

TL;DR: A 67-year-old woman presented with a 20-year history of proctalgia fugax and outlet obstruction and other family members were similarly affected, illustrating the potential importance of histopathological studies of smooth muscle in functional disorders of the gut.

TL;DR: Changes in neuronal proteins are described as a result of surgical tractotomy on the human spinal cord at 3, 5, 7, 14 and 72 days after operation, suggesting that the intraneuronal ubiquitinated inclusions may have a unique significance in the cytopathology of that disorder.

TL;DR: Small bodies expressing epitopes of the 72 kD heat shock protein (HSP) have been identified in the brain and spinal cord in normal and neurologically abnormal individuals.

TL;DR: The data prove the physiological role of BACE2 as a dose-sensitive AD-suppressor gene, potentially explaining the dementia delay in ∼30% of people with DS, and show that DS cerebral organoids could be explored as pre-morbid AD-risk population detector and a system for hypothesis-free drug screens as well as identification of natural suppressor genes for neurodegenerative diseases.

TL;DR: In two members of an affected family with a hereditary syndrome of proctalgia fugax and constipation, a hypertro‐phied internal anal sphincter was found with histological features suggesting a myopathy of this muscle.