J
João Costa Pessoa
Researcher at Instituto Superior Técnico
Publications - 189
Citations - 7094
João Costa Pessoa is an academic researcher from Instituto Superior Técnico. The author has contributed to research in topics: Ligand & Catalysis. The author has an hindex of 48, co-authored 180 publications receiving 6066 citations. Previous affiliations of João Costa Pessoa include University of Lisbon & Indian Institute of Technology Roorkee.
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Journal ArticleDOI
Vanadium compounds in medicine.
TL;DR: This work reviews the medicinal applications proposed for vanadium compounds with particular emphasis on the more recent publications and concludes that the potential ofVanadium compounds to treat type 2 diabetes is still an open question and therapies using vanadium compound for e.g. antitumor and anti-parasitic related diseases remain promising.
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In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds
Dieter Rehder,João Costa Pessoa,Carlos F. G. C. Geraldes,M. Margarida C. A. Castro,Themistoklis A. Kabanos,Tamás Kiss,Beate Meier,Giovanni Micera,Lage Pettersson,Maria Rangel,Athanasios Salifoglou,Iztok Turel,Dongren Wang +12 more
TL;DR: There is no striking correlation between the nature of the ligand systems and the insulin-mimetic potency in these cell culture tests, encompassing 41 vanadium compounds, the results on 22 of which are reported in detail here.
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Synthesis, characterization, and application of vanadium-salan complexes in oxygen transfer reactions.
Pedro Adão,João Costa Pessoa,Rui T. Henriques,Maxim L. Kuznetsov,Fernando Avecilla,Mannar R. Maurya,Umesh Kumar,Isabel Correia +7 more
TL;DR: The V-Salen and V-salan complexes show higher activity and normally better selectivity in alkene oxidation and higherActivity and enantioselectivity for sulfoxidation than their parent V- salen complexes, therefore being an advantageous alternative ligand system for oxidation catalysis.
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Vanadium and proteins: Uptake, transport, structure, activity and function
TL;DR: The ability of vanadium to interfere with the metabolic processes involving Ca2+ and Mg2+, connected with its versatility to undergo changes in coordination geometry, allow V to influence the function of a large variety of phosphate-metabolizing enzymes and vanadate(V) salts and compounds have been frequently used either as inhibitors of these enzymes, or as probes to study the mechanisms of their reactions and catalytic cycle.
Journal ArticleDOI
Biospeciation of antidiabetic VO(IV) complexes
Tamás Kiss,Tamás Kiss,Tamás Jakusch,Dominik Hollender,Ágnes Dörnyei,Éva A. Enyedy,João Costa Pessoa,Hiromu Sakurai,Alfredo Sanz-Medel +8 more
TL;DR: The results suggest that decomposition and subsequent ternary complex formation with endogenous or exogenous ligands in the organism affects the absorption efficacy of the originally neutral VO(IV) compounds considerably.