Vanadium compounds in medicine.
TLDR
This work reviews the medicinal applications proposed for vanadium compounds with particular emphasis on the more recent publications and concludes that the potential ofVanadium compounds to treat type 2 diabetes is still an open question and therapies using vanadium compound for e.g. antitumor and anti-parasitic related diseases remain promising.About:
This article is published in Coordination Chemistry Reviews.The article was published on 2015-10-15 and is currently open access. It has received 373 citations till now. The article focuses on the topics: Vanadium.read more
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Journal ArticleDOI
Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus
Samuel Treviño,Alfonso Díaz,Eduardo Sánchez-Lara,Brenda L. Sanchez-Gaytan,Jose Manuel Perez-Aguilar,Enrique González-Vergara +5 more
TL;DR: This review examines the development of vanadium-containing compounds in biological systems regarding the role of the physiological environment, dosage, intracellular interactions, metabolic transformations, modulation of signaling pathways, toxicology, and transport and tissue distribution as well as therapeutic implications and sheds light on the prevailing gaps between primary scientific data and information from animal models and human studies.
Journal ArticleDOI
Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities
TL;DR: The main cellular uptake pathways of metal compounds, including passive diffusion, active uptake through transport channels and endocytosis-mediated uptake, provide a link between chemical forms of the metal species in the medium and their biological activities, leading to conflicting evidence of activities.
Journal ArticleDOI
Thirty years through vanadium chemistry.
TL;DR: The relevance of vanadium in biological systems is known for many years and vanadium-based catalysts have important industrial applications, however, until the beginning of the 80s research on vanadium chemistry and biochemistry did not receive much attention from the scientific community.
Journal ArticleDOI
Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends.
TL;DR: This review aims at summarizing the current state of knowledge of the pharmacological potential of V and the mechanisms underlying its anti-viral, anti-bacterial,Anti-parasitic,anti-fungal, pro-cancer, anti-, anti-diabetic, and neuroprotective activity as well as the mechanisms of appetite regulation related to the possibility of using this element in the treatment of obesity.
Journal ArticleDOI
Vanadium ionic species from degradation of Ti-6Al-4V metallic implants: In vitro cytotoxicity and speciation evaluation.
Bruna Carolina Costa,Cintia Kazuko Tokuhara,Luís Augusto Rocha,Rodrigo Cardoso de Oliveira,Paulo Noronha Lisboa-Filho,João Costa Pessoa +5 more
TL;DR: Even though relatively low concentrations of vanadium may be released from Ti-6Al-4V implants in vivo, the continuous contact with peri-implant cells for long periods of time may represent a potentially hazardous situation.
References
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
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Mammalian MAP kinase signalling cascades
Lufen Chang,Michael Karin +1 more
TL;DR: Recent studies have begun to shed light on the physiological functions of MAPK cascades in the control of gene expression, cell proliferation and programmed cell death.
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Comprehensive inorganic chemistry
TL;DR: In this article, the transition elements involving metal-metal bonds are defined and an introductory essay is given, along with a discussion of homogeneous catalysis and transition metal chemistry, B L Shaw & N I Tucker.