Johan C. de Jongste

TL;DR: Fractional exhaled nitric oxide in healthy children is below 15 to 25 ppb depending on age and self-reported atopy, and higher FE NO was seen in children with self- reported rhinitis/conjunctivitis or hay fever.

TL;DR: High-quality studies indicated that better adherence is associated with fewer severe asthma exacerbations in high- quality studies, and future studies should use standardised methodology to assess adherence and exacerbations, and should consider inhaler competence.

TL;DR: The authors used longitudinal latent class analysis to identify phenotypes on the basis of repeated reports of wheezing from 0 to 8 years in 5760 children from the Avon Longitudinal Study of Parents And Children (ALSPAC) and 2810 children from PIAMA study.

TL;DR: Primary airway malacia is not rare in the general population, with an estimated incidence of at least 1 in 2,100 children, and bronchoscopy is recommended in patients with impaired exercise tolerance, recurrent lower airways infection, and therapy-resistant, irreversible, and/or atypical asthma to rule out airwaymalacia.

TL;DR: Supplementation of CRL431 and Bb-12 to extensively hydrolyzed formula does not accelerate CM tolerance in infants with CMA and the cumulative percentage of tolerance to CM at 6 and 12 months was similar in both groups.