G
Gerard H. Koppelman
Researcher at University Medical Center Groningen
Publications - 476
Citations - 24765
Gerard H. Koppelman is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Asthma & Population. The author has an hindex of 77, co-authored 436 publications receiving 20029 citations. Previous affiliations of Gerard H. Koppelman include University of Pittsburgh & Boston Children's Hospital.
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Journal ArticleDOI
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
Daniel F. Gudbjartsson,Unnur S. Bjornsdottir,Unnur S. Bjornsdottir,Eva Halapi,Anna Helgadottir,Patrick Sulem,Gudrun M. Jonsdottir,Gudmar Thorleifsson,Hafdis T. Helgadottir,Valgerdur Steinthorsdottir,Hreinn Stefansson,Carolyn Williams,Jennie Hui,John Beilby,Nicole M. Warrington,Alan L. James,Alan L. James,Lyle J. Palmer,Gerard H. Koppelman,Andrea Heinzmann,Marcus Krueger,H. Marike Boezen,Amanda Wheatley,Janine Altmüller,Hyoung Doo Shin,Soo-Taek Uh,Hyun Sub Cheong,Brynja Jonsdottir,David Gislason,Choon-Sik Park,Linda M. Rasmussen,Celeste Porsbjerg,Jakob Werner Hansen,Vibeke Backer,Thomas Werge,Christer Janson,Ulla-Britt Jönsson,Maggie C.Y. Ng,Juliana C.N. Chan,Wing-Yee So,Ronald C.W. Ma,Svati H. Shah,Christopher B. Granger,Arshed A. Quyyumi,Allan I. Levey,Viola Vaccarino,Muredach P. Reilly,Daniel J. Rader,Michael J.A. Williams,Andre M. van Rij,Gregory T. Jones,Elisabetta Trabetti,Giovanni Malerba,Pier Franco Pignatti,Attilio Boner,Lydia Pescollderungg,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Bjorn R. Ludviksson,Dora Ludviksdottir,Gudmundur I. Eyjolfsson,David O. Arnar,Gudmundur Thorgeirsson,Klaus A. Deichmann,Philip J. Thompson,Matthias Wjst,Ian P. Hall,Dirkje S. Postma,Thorarinn Gislason,Jeffrey R. Gulcher,Augustine Kong,Ingileif Jonsdottir,Ingileif Jonsdottir,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +77 more
TL;DR: A genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly with myocardial infarction in six different populations.
Journal ArticleDOI
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Bonnie R. Joubert,Janine F. Felix,Paul Yousefi,Kelly M. Bakulski,Allan C. Just,Carrie V. Breton,Sarah E. Reese,Christina A. Markunas,Christina A. Markunas,Rebecca C Richmond,Cheng-Jian Xu,Leanne K. Küpers,Sam S. Oh,Cathrine Hoyo,Olena Gruzieva,Cilla Söderhäll,Lucas A. Salas,Nour Baïz,Hongmei Zhang,Johanna Lepeule,Carlos Ruiz,Symen Ligthart,Tianyuan Wang,Jack A. Taylor,Liesbeth Duijts,Gemma C Sharp,Soesma A Jankipersadsing,Roy Miodini Nilsen,Ahmad Vaez,Ahmad Vaez,M. Daniele Fallin,Donglei Hu,Augusto A. Litonjua,Bernard F. Fuemmeler,Karen Huen,Juha Kere,Inger Kull,Monica Cheng Munthe-Kaas,Ulrike Gehring,Mariona Bustamante,Marie José Saurel-Coubizolles,Bilal M. Quraishi,Jie Ren,Jörg Tost,Juan R. González,Marjolein J. Peters,Siri E. Håberg,Zongli Xu,Joyce B. J. van Meurs,Tom R. Gaunt,Marjan Kerkhof,Eva Corpeleijn,Andrew P. Feinberg,Celeste Eng,Andrea A. Baccarelli,Sara E. Benjamin Neelon,Asa Bradman,Simon Kebede Merid,Anna Bergström,Zdenko Herceg,Hector Hernandez-Vargas,Bert Brunekreef,Mariona Pinart,Barbara Heude,Susan Ewart,Jin Yao,Nathanaël Lemonnier,Oscar H. Franco,Michael C. Wu,Albert Hofman,Albert Hofman,Wendy L. McArdle,Pieter van der Vlies,Fahimeh Falahi,Matthew W. Gillman,Lisa F. Barcellos,Ashok Kumar,Ashok Kumar,Ashok Kumar,Magnus Wickman,Magnus Wickman,Stefano Guerra,Marie-Aline Charles,John W. Holloway,Charles Auffray,Henning Tiemeier,George Davey Smith,Dirkje S. Postma,Marie-France Hivert,Brenda Eskenazi,Martine Vrijheid,Hasan Arshad,Josep M. Antó,Abbas Dehghan,Wilfried Karmaus,Isabella Annesi-Maesano,Jordi Sunyer,Akram Ghantous,Göran Pershagen,Nina Holland,Susan K. Murphy,Dawn L. DeMeo,Esteban G. Burchard,Christine Ladd-Acosta,Harold Snieder,Wenche Nystad,Gerard H. Koppelman,Caroline L Relton,Vincent W. V. Jaddoe,Allen J. Wilcox,Erik Melén,Erik Melén,Stephanie J. London +112 more
TL;DR: This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Journal ArticleDOI
A cellular census of human lungs identifies novel cell states in health and in asthma.
Felipe A. Vieira Braga,Gozde Kar,Marijn Berg,Orestes A Carpaij,Krzysztof Polanski,Lukas M. Simon,Sharon Brouwer,Tomás Gomes,Laura Hesse,Jian Jiang,Eirini S. Fasouli,Mirjana Efremova,Roser Vento-Tormo,Carlos Talavera-López,Marnix R. Jonker,Karen Affleck,Subarna Palit,Paulina M. Strzelecka,Paulina M. Strzelecka,Helen V. Firth,Krishnaa T. Mahbubani,Ana Cvejic,Ana Cvejic,Kerstin B. Meyer,Kourosh Saeb-Parsy,Marjan Luinge,Corry-Anke Brandsma,Wim Timens,Ilias Angelidis,Maximilian Strunz,Gerard H. Koppelman,Antoon J. M. van Oosterhout,Herbert B. Schiller,Fabian J. Theis,Maarten van den Berge,Martijn C. Nawijn,Sarah A. Teichmann,Sarah A. Teichmann +37 more
TL;DR: Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs.
Journal ArticleDOI
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Lavinia Paternoster,Marie Standl,Johannes Waage,H. Baurecht,Melanie Hotze,David P. Strachan,John A. Curtin,Klaus Bønnelykke,Chao Tian,Atsushi Takahashi,Jorge Esparza-Gordillo,Alexessander Couto Alves,Jacob P. Thyssen,Herman T. den Dekker,Manuel A. R. Ferreira,Elisabeth Altmaier,Patrick M. A. Sleiman,Patrick M. A. Sleiman,Feng Li Xiao,Juan R. González,Juan R. González,Ingo Marenholz,Birgit Kalb,Maria Pino-Yanes,Maria Pino-Yanes,Cheng-Jian Xu,Lisbeth Carstensen,Maria M. Groen-Blokhuis,Cristina Venturini,Craig E. Pennell,Sheila J. Barton,Albert M. Levin,Ivan Curjuric,Ivan Curjuric,Mariona Bustamante,Eskil Kreiner-Møller,Gabrielle A. Lockett,Jonas Bacelis,Supinda Bunyavanich,Rachel A. Myers,Anja Matanovic,Ashok Kumar,Joyce Y. Tung,Tomomitsu Hirota,Michiaki Kubo,Wendy L. McArdle,A. John Henderson,John P. Kemp,John P. Kemp,Jie Zheng,George Davey Smith,Franz Rueschendorf,Anja Bauerfeind,Min Ae Lee-Kirsch,Andreas Arnold,Georg Homuth,Carsten Oliver Schmidt,Elisabeth Mangold,Sven Cichon,Thomas Keil,Elke Rodriguez,Annette Peters,Andre Franke,Wolfgang Lieb,Natalija Novak,Regina Foelster-Holst,Momoko Horikoshi,Juha Pekkanen,Sylvain Sebert,Lise Lotte N. Husemoen,Niels Grarup,Johan C. de Jongste,Fernando Rivadeneira,Albert Hofman,Vincent W. V. Jaddoe,Suzanne G.M.A. Pasmans,Niels J. Elbert,André G. Uitterlinden,Guy B. Marks,Philip J. Thompson,Melanie C. Matheson,Colin F. Robertson,Janina S. Ried,Jin Li,Xian Bo Zuo,X. Zheng,Xianyong Yin,Liangdan Sun,Maeve A. McAleer,Grainne M. O'Regan,Caoimhe M. R. Fahy,Linda E. Campbell,Milan Macek,Michael Kurek,Donglei Hu,Celeste Eng,Dirkje S. Postma,Bjarke Feenstra,Frank Geller,Jouke-Jan Hottenga,Christel M. Middeldorp,Pirro G. Hysi,Veronique Bataille,Tim D. Spector,Carla M. T. Tiesler,Elisabeth Thiering,Badri Pahukasahasram,James J. Yang,Medea Imboden,Scott Huntsman,Natalia Vilor-Tejedor,Caroline L Relton,Ronny Myhre,Wenche Nystad,Adnan Custovic,Scott T. Weiss,Deborah A. Meyers,Cilla Soederhaell,Erik Melén,Carole Ober,Benjamin A. Raby,Angela Simpson,Bo Jacobsson,John W. Holloway,Hans Bisgaard,Jordi Sunyer,Nicole Probst-Hensch,L. Keoki Williams,Keith M. Godfrey,Carol A. Wang,Dorret I. Boomsma,Mads Melbye,Gerard H. Koppelman,Deborah Jarvis,W.H. Irwin McLean,Alan D. Irvine,Xuejun Zhang,Hakon Hakonarson,Christian Gieger,Esteban G. Burchard,Nicholas G. Martin,Liesbeth Duijts,Allan Linneberg,Marjo-Riitta Järvelin,Markus M. Noethen,Susanne Lau,Norbert Huebner,Young-Ae Lee,Mayumi Tamari,David A. Hinds,Daniel Glass,Sara J. Brown,Joachim Heinrich,David M. Evans,Stephan Weidinger +154 more
TL;DR: This paper performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies.
Journal ArticleDOI
Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs
Jean Bousquet,Holger J. Schünemann,B. Samolinski,Pascal Demoly,Carlos E. Baena-Cagnani,Carlos E. Baena-Cagnani,Claus Bachert,Sergio Bonini,L.-P. Boulet,Philippe-Jean Bousquet,Jan Brozek,Giorgio Walter Canonica,Thomas B. Casale,Alvaro A. Cruz,W. J. Fokkens,João Fonseca,R. Gerth van Wijk,Lawrence Grouse,Tari Haahtela,N. Khaltaev,Piotr Kuna,Richard F. Lockey,K. C. Lødrup Carlsen,J Mullol,Robert M. Naclerio,Robyn E O'Hehir,K. Ohta,S. Palkonen,Nikolaos G. Papadopoulos,G. Passalacqua,Ruby Pawankar,David Price,Dermot Ryan,F. E. R. Simons,Alkis Togias,Dennis M. Williams,A. Yorgancioglu,Osman M. Yusuf,Werner Aberer,Mitsuru Adachi,Ioana Agache,Nadia Aït-Khaled,Cezmi A. Akdis,A. Andrianarisoa,I. Annesi-Maesano,I. Annesi-Maesano,I. J. Ansotegui,Ilaria Baiardini,Eric D. Bateman,A. Bedbrook,Bianca Beghe,M. Beji,E.H.D. Bel,A. Ben Kheder,K. S. Bennoor,K. C. Bergmann,F. Berrissoul,T. Bieber,C. Bindslev Jensen,Michael S. Blaiss,A. L. Boner,Jacques Bouchard,Fulvio Braido,Christopher E. Brightling,Andrew Bush,F. Caballero,Moises A. Calderon,M. A. Calvo,Paulo Augusto Moreira Camargos,Luis Caraballo,Kai-Håkon Carlsen,W. Carr,Alfonso Cepeda,Alfredo Cesario,Niels H. Chavannes,Y. Z. Chen,Anca-Mirela Chiriac,T. Chivato Pérez,E. Chkhartishvili,Giorgio Ciprandi,D. J. Costa,L. Cox,Adnan Custovic,Ronald Dahl,Ulf Darsow,F. De Blay,Diana Deleanu,Judah A. Denburg,P. Devillier,T. Didi,D. Dokic,William K. Dolen,H. Douagui,Ruta Dubakiene,Stephen R. Durham,Mark S. Dykewicz,Yehia El-Gamal,A. El-Meziane,R. Emuzyte,Alessandro Fiocchi,Monica Fletcher,Takeshi Fukuda,Amiran Gamkrelidze,J. E. Gereda,S. Gonzalez Diaz,M. Gotua,M. A. Guzman,P W Hellings,B. Hellquist-Dahl,Friedrich Horak,J. O. B. Hourihane,Peter H. Howarth,Marc Humbert,Juan Carlos Ivancevich,Catherine Jackson,J. Just,O. Kalayci,Michael A. Kaliner,Ali Fuat Kalyoncu,Thomas Keil,Paul K. Keith,G. Khayat,You Young Kim,B. Koffi N'Goran,Gerard H. Koppelman,Marek L. Kowalski,Inger Kull,Violeta Kvedariene,Désirée Larenas-Linnemann,L. T. Le,Catherine Lemière,Jing Li,Phillip Lieberman,Brian J. Lipworth,Bassam Mahboub,Mika J. Mäkelä,Finbarr C. Martin,Gailen D. Marshall,Fernando D. Martinez,Mohammad Reza Masjedi,Marcus Maurer,S. Mavale-Manuel,Angel Mazon,Erik Melén,Eli O. Meltzer,N. H. Mendez,Hans F. Merk,F. Mihaltan,Yousser Mohammad,M. Morais-Almeida,Antonella Muraro,S. Nafti,Leyla Namazova-Baranova,K. Nekam,Angelo Neou,Bodo Niggemann,Ewa Nizankowska-Mogilnicka,T. D. Nyembue,Y. Okamoto,Kimi Okubo,M. P. Orru,S. Ouedraogo,Cevdet Ozdemir,P. Panzner,Isabella Pali-Schöll,Hae-Sim Park,B. Pigearias,W. Pohl,Todor A. Popov,Dirkje S. Postma,Paul Potter,Klaus F. Rabe,J. Ratomaharo,Sakari Reitamo,J. Ring,Ronald C. Roberts,Barbara Rogala,Antonino Romano,M. Roman Rodriguez,J Rosado-Pinto,Lanny J. Rosenwasser,Menachem Rottem,Menachem Rottem,Mario Sánchez-Borges,G. K. Scadding,Peter Schmid-Grendelmeier,Aziz Sheikh,J. C. Sisul,Dirceu Solé,Talant Sooronbaev,V. Spicak,O. Spranger,Renato T. Stein,Stuart W. Stoloff,Jordi Sunyer,Andrzej Szczeklik,Ana Todo-Bom,Elina Toskala,Elina Toskala,Y. Tremblay,Rudolf Valenta,Antonio Valero,Dominique Valeyre,Arunas Valiulis,Erkka Valovirta,P. Van Cauwenberge,Olivier Vandenplas,C. van Weel,Pakit Vichyanond,Giovanni Viegi,Dai Wang,Magnus Wickman,Stefan Wöhrl,John Wright,Barbara P. Yawn,Panayiotis K. Yiallouros,H. J. Zar,M. E. Zernotti,Nanshan Zhong,Mihaela Zidarn,Torsten Zuberbier,C. S. Ang,Abay Baigenzhin,Daniel A. Boakye,Andrew Briggs,Peter Burney,William W. Busse,A.G. Chuchalin,H. Haddad,Sebastian L. Johnston,Manolis Kogevinas,Mark L Levy,Alireza Mohammadi,Sam Oddie,D. Rezagui,Ingrid Terreehorst,John O. Warner +236 more
TL;DR: Ten years after the publication of the ARIA World Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children.