J
Johanna Lempainen
Researcher at Turku University Hospital
Publications - 52
Citations - 2223
Johanna Lempainen is an academic researcher from Turku University Hospital. The author has contributed to research in topics: Medicine & Type 1 diabetes. The author has an hindex of 15, co-authored 34 publications receiving 1454 citations. Previous affiliations of Johanna Lempainen include University of Turku.
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Journal ArticleDOI
Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children
Anette-G. Ziegler,Marian Rewers,Olli Simell,Tuula Simell,Johanna Lempainen,Andrea K. Steck,Christiane Winkler,Jorma Ilonen,Riitta Veijola,Mikael Knip,Ezio Bonifacio,George S. Eisenbarth +11 more
TL;DR: The majority of children at risk of type 1 diabetes who had multiple islet autoantibody seroconversion progressed to diabetes over the next 15 years, and future prevention studies should focus on this high-risk population.
Journal ArticleDOI
The heterogeneous pathogenesis of type 1 diabetes mellitus
TL;DR: The latest developments in understanding the heterogeneity of T1DM and characterization of major disease subtypes might help in the development of preventive treatments and expected developments in the near future are described.
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COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants.
Pinja Jalkanen,Pekka Kolehmainen,Hanni K. Häkkinen,Moona Huttunen,Paula A. Tähtinen,Rickard Lundberg,Sari Maljanen,Arttu Reinholm,Sisko Tauriainen,Sari H. Pakkanen,Iris Levonen,Arttu Nousiainen,Taru Miller,Hanna Välimaa,Lauri Ivaska,Arja Pasternack,Rauno Naves,Olli Ritvos,Pamela Österlund,Suvi Kuivanen,Teemu Smura,Jussi Hepojoki,Olli Vapalahti,Johanna Lempainen,Johanna Lempainen,Laura Kakkola,Anu Kantele,Ilkka Julkunen,Ilkka Julkunen +28 more
TL;DR: Jalkanen et al. as mentioned in this paper showed that after the second dose of BNT162b2-vaccinated health care workers (n = 180) effectively neutralized the SARS-CoV-2 variant with the D614G substitution and the B.1.7 variant, whereas the neutralization of B.351 variant is five-fold reduced.
Journal ArticleDOI
Patterns of β-cell autoantibody appearance and genetic associations during the first years of life.
Jorma Ilonen,Anna Hammais,Antti-Pekka Laine,Johanna Lempainen,Johanna Lempainen,Outi Vaarala,Riitta Veijola,Riitta Veijola,Olli Simell,Olli Simell,Mikael Knip +10 more
TL;DR: The primary autoantigen in the development of β-cell autoimmunity and T1D seems to strongly correlate with age and genetic factors, indicating heterogeneity in the initiation of the disease process.
Journal ArticleDOI
Genetic susceptibility to type 1 diabetes in childhood – estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity
Jorma Ilonen,Minna Kiviniemi,Johanna Lempainen,Olli Simell,Jorma Toppari,Jorma Toppari,Riitta Veijola,Mikael Knip +7 more
TL;DR: A simple risk estimation based on HLA class II genotyping was developed, which was also tested by analyzing HLAclass II effect on the autoantibody seroconversion and further progression to diabetes.