A
Anette-G. Ziegler
Researcher at Technische Universität München
Publications - 343
Citations - 20787
Anette-G. Ziegler is an academic researcher from Technische Universität München. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 68, co-authored 294 publications receiving 17371 citations. Previous affiliations of Anette-G. Ziegler include München Klinik Bogenhausen & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
Bart Keymeulen,Evy Vandemeulebroucke,Anette-G. Ziegler,Chantal Mathieu,Leonard Kaufman,Geoff Hale,Frans Gorus,Michel Goldman,M Walter,Sophie Candon,Liliane Schandené,Laurent Crenier,Christophe De Block,Jean-Marie Seigneurin,Pieter De Pauw,Denis Pierard,Ilse Weets,Peppy Rebello,Pru Bird,Eleanor Berrie,Mark Frewin,Herman Waldmann,Jean-François Bach,Daniel Pipeleers,Lucienne Chatenoud +24 more
TL;DR: Short-term treatment with CD3 antibody preserves residual beta-cell function for at least 18 months in patients with recent-onset type 1 diabetes, as suggested by the results of a phase 1 study.
Journal ArticleDOI
Temporal development of the gut microbiome in early childhood from the TEDDY study
Christopher J. Stewart,Christopher J. Stewart,Nadim J. Ajami,Jacqueline O'Brien,Diane S. Hutchinson,Daniel P. Smith,Matthew C. Wong,Matthew C. Ross,Richard E. Lloyd,Harshavardhan Doddapaneni,Ginger A. Metcalf,Donna M. Muzny,Richard A. Gibbs,Tommi Vatanen,Curtis Huttenhower,Ramnik J. Xavier,Marian Rewers,William Hagopian,Jorma Toppari,Jorma Toppari,Anette-G. Ziegler,Jin-Xiong She,Beena Akolkar,Åke Lernmark,Heikki Hyöty,Kendra Vehik,Jeffrey P. Krischer,Joseph F. Petrosino +27 more
TL;DR: Analysis of stool samples from 903 children as part of the TEDDY study shows that breastfeeding was the most important factor associated with microbiome structure, and the cessation of breast milk resulted in faster maturation of the gut microbiome.
Journal ArticleDOI
Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children
Anette-G. Ziegler,Marian Rewers,Olli Simell,Tuula Simell,Johanna Lempainen,Andrea K. Steck,Christiane Winkler,Jorma Ilonen,Riitta Veijola,Mikael Knip,Ezio Bonifacio,George S. Eisenbarth +11 more
TL;DR: The majority of children at risk of type 1 diabetes who had multiple islet autoantibody seroconversion progressed to diabetes over the next 15 years, and future prevention studies should focus on this high-risk population.
Journal ArticleDOI
Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Richard A. Insel,Jessica L. Dunne,Mark A. Atkinson,Jane L. Chiang,Dana Dabelea,Peter A. Gottlieb,Carla J. Greenbaum,Kevan C. Herold,Jeffrey P. Krischer,Åke Lernmark,Robert E. Ratner,Marian Rewers,Desmond A. Schatz,Jay S. Skyler,Jay M. Sosenko,Anette-G. Ziegler +15 more
TL;DR: Adoption of this staging classification provides a standardized taxonomy for type 1 diabetes and will aid the development of therapies and the design of clinical trials to prevent symptomatic disease, promote precision medicine, and provide a framework for an optimized benefit/risk ratio.
Journal ArticleDOI
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.
TL;DR: Presentation of IAAs is a consistent feature of this autoimmunity, and IAA detection can identify children at risk, and IAAs were detected most frequently.