J
Johannes Burtscher
Researcher at University of Lausanne
Publications - 102
Citations - 1624
Johannes Burtscher is an academic researcher from University of Lausanne. The author has contributed to research in topics: Medicine & Neurodegeneration. The author has an hindex of 14, co-authored 68 publications receiving 773 citations. Previous affiliations of Johannes Burtscher include MIND Institute & University of Innsbruck.
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The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Anne-Laure Mahul-Mellier,Johannes Burtscher,Niran Maharjan,Laura Weerens,Marie Croisier,Fabien Kuttler,Marion Leleu,Graham Knott,Hilal A. Lashuel +8 more
TL;DR: A neuronal model that reproduces the key events leading to the formation of inclusions that recapitulate the biochemical, structural, and organizational features of bona fide LBs is described, providing a powerful platform for evaluating therapeutics targeting α-synuclein aggregation and LB formation and to identify and validate therapeutic targets for the treatment of Parkinson’s disease.
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(Indoor) isolation, stress, and physical inactivity: Vicious circles accelerated by COVID-19?
TL;DR: The Covid‐19 epidemic necessitates the application of strict isolation strategies to curb virus spreading but causes chronic stress and is associated with a burden on mental health, posing risk factors for anxiety and depression.
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Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity.
TL;DR: It is argued that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2, and markers of mitochondrial functions promising potential biomarkers for Sars-Cov-2 infection risk and severity of outcome are identified.
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Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry.
TL;DR: R respirometric OXPHOS analysis provides a very sensitive diagnostic approach using small amounts of distinct brain tissues as indicators of tissue-specific mitochondrial performance, and suggests flux control ratios as a valid method to normalize respiration to mitochondrial density.
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Extreme Terrestrial Environments: Life in Thermal Stress and Hypoxia. A Narrative Review.
TL;DR: This review provides an overview of the physiological and morphological aspects of adaptive responses in these environmental stressors at the level of organs, tissues, and cells for general adaptability of humans.