Johannes Burtscher

TL;DR: A neuronal model that reproduces the key events leading to the formation of inclusions that recapitulate the biochemical, structural, and organizational features of bona fide LBs is described, providing a powerful platform for evaluating therapeutics targeting α-synuclein aggregation and LB formation and to identify and validate therapeutic targets for the treatment of Parkinson’s disease.

TL;DR: The Covid‐19 epidemic necessitates the application of strict isolation strategies to curb virus spreading but causes chronic stress and is associated with a burden on mental health, posing risk factors for anxiety and depression.

TL;DR: It is argued that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2, and markers of mitochondrial functions promising potential biomarkers for Sars-Cov-2 infection risk and severity of outcome are identified.

TL;DR: R respirometric OXPHOS analysis provides a very sensitive diagnostic approach using small amounts of distinct brain tissues as indicators of tissue-specific mitochondrial performance, and suggests flux control ratios as a valid method to normalize respiration to mitochondrial density.

TL;DR: This review provides an overview of the physiological and morphological aspects of adaptive responses in these environmental stressors at the level of organs, tissues, and cells for general adaptability of humans.