J
John A. Barnard
Researcher at Vanderbilt University
Publications - 47
Citations - 4569
John A. Barnard is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Transforming growth factor & Autocrine signalling. The author has an hindex of 20, co-authored 45 publications receiving 4466 citations.
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Journal ArticleDOI
Targeted Disruption of Mouse EGF Receptor: Effect of Genetic Background on Mutant Phenotype
David W. Threadgill,Andrzej A. Dlugosz,Laura A. Hansen,Tamar Tennenbaum,Ulrike Lichti,Della Yee,Christian LaMantia,Tracy Mourton,Karl Herrup,Raymond C. Harris,John A. Barnard,Stuart H. Yuspa,Robert J. Coffey,Terry Magnuson +13 more
TL;DR: The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
Journal ArticleDOI
The cell biology of transforming growth factor β
TL;DR: The present review has summarized many of the recent studies that have just begun to conceptually integrate this expanding array of TGF beta functions into the context of a three-dimensional, multicellular organ or tissue, be it normal or diseased.
Journal ArticleDOI
Regulation of intestinal epithelial cell growth by transforming growth factor type beta
TL;DR: It is concluded that TGF-beta 1 is an autoregulated growth inhibitor in IEC-6 cells that potentially functions in an autocrine manner and may function in coordination of the rapid cell turnover typical for the intestinal epithelium.
Journal ArticleDOI
Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology.
John A. Barnard,R. Daniel Beauchamp,William E. Russell,Raymond N. DuBois,Raymond N. DuBois,Robert J. Coffey,Robert J. Coffey +6 more
TL;DR: The biology and significance of the epidermal growth factor (EGF) family is reviewed, with particular emphasis on understanding the integrated function of the family and the relationships between family members in the context of gastrointestinal physiology and pathophysiology.
Journal Article
Butyrate Rapidly Induces Growth Inhibition and Differentiation in HT-29 Cells'
TL;DR: Data indicate that butyrate arrests HT-29 cell growth early in G1, and alkaline phosphatase mRNA expression was temporally associated with a 5-fold increase in expression of transforming growth factor beta 1 (TGF-beta 1) mRNA.