Journal ArticleDOI
Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology.
John A. Barnard,R. Daniel Beauchamp,William E. Russell,Raymond N. DuBois,Raymond N. DuBois,Robert J. Coffey,Robert J. Coffey +6 more
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TLDR
The biology and significance of the epidermal growth factor (EGF) family is reviewed, with particular emphasis on understanding the integrated function of the family and the relationships between family members in the context of gastrointestinal physiology and pathophysiology.Citations
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Targeted Disruption of Mouse EGF Receptor: Effect of Genetic Background on Mutant Phenotype
David W. Threadgill,Andrzej A. Dlugosz,Laura A. Hansen,Tamar Tennenbaum,Ulrike Lichti,Della Yee,Christian LaMantia,Tracy Mourton,Karl Herrup,Raymond C. Harris,John A. Barnard,Stuart H. Yuspa,Robert J. Coffey,Terry Magnuson +13 more
TL;DR: The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
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Myofibroblasts. I. Paracrine cells important in health and disease.
TL;DR: Myofibroblasts are a unique group of smooth-muscle-like fibro-blasts that have a similar appearance and function regardless of their tissue of residence as discussed by the authors.
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A family of tissue-specific resistin-like molecules
Claire M. Steppan,Elizabeth J. Brown,Christopher M. Wright,Savitha Bhat,Ronadip R. Banerjee,Charlotte Y. Dai,Gregory H. Enders,Debra G. Silberg,Xiaoming Wen,Gary D. Wu,Mitchell A. Lazar +10 more
TL;DR: The RELMs together with resistin comprise a class of tissue-specific signaling molecules that share a cysteine composition and other signature features and suggest a role in intestinal proliferation.
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Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion
TL;DR: The role of human saliva and its compositional elements in relation to the GI functions of taste, mastication, bolus formation, enzymatic digestion, and swallowing is reviewed.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.
References
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Journal ArticleDOI
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
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Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal
TL;DR: The isolation of the factor responsible for the earlier development of the incisors and eyelids is reported here, a heat-stable, nondialysable, antigenic protein, whose most distinctive chemical characteristic is the absence of phenylalanine and lysine.
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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
TL;DR: Results show that, depending on cellular context, activation of MAP kinase kinase is necessary and sufficient for cell differentiation or proliferation.