J
John A. McGrath
Researcher at King's College London
Publications - 674
Citations - 26684
John A. McGrath is an academic researcher from King's College London. The author has contributed to research in topics: Epidermolysis bullosa & Mutation. The author has an hindex of 75, co-authored 631 publications receiving 24078 citations. Previous affiliations of John A. McGrath include Ninewells Hospital & Southampton General Hospital.
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Journal ArticleDOI
Oral and gastrointestinal manifestations of epidermolysis bullosa.
Simon Travis,John A. McGrath,A J Turnbull,O.M.V. Schofield,O Chan,Alec Fitzgerald O'Connor,B.J. Mayou,Robin A.J. Eady,Richard P. H. Thompson +8 more
TL;DR: Lingual adhesions or microstomia occurred in dystrophic epidermolysis bullosa only, but were eight times more common in recessive than in dominant subtypes.
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Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas
Atte Kivisaari,Markku Kallajoki,Tuomas Mirtti,John A. McGrath,Johann W. Bauer,F. Weber,R Konigova,Daisuke Sawamura,Kazuko C. Sato-Matsumura,Hiroshi Shimizu,Márta Csikós,K Sinemus,W. Beckert,Veli-Matti Kähäri +13 more
TL;DR: Patients with recessive dystrophic epidermolysis bullosa (RDEB) have an increased risk of developing rapidly progressive and metastatic cutaneous squamous cell carcinomas (SCC), and Matrix metalloproteinases (MMP) are a family of endopeptidases that contribute to growth, invasion and metastasis of SCC.
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Detection of sequence variants in the gene encoding the β3 chain of laminin 5 (LAMB3)
TL;DR: Primer pairs for the amplification of the complete cDNA as well as 22 exons of the LAMB3 gene encoding the entire β3 chain of laminin 5 are established, demonstrating that this method is useful in the detection of JEB mutations, aswell as polymorphisms in the Lamington3 gene.
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Ultrastructural Clues to Genetic Disorders of Skin: The Dermal-Epidermal Junction
TL;DR: Electron microscopy has had a unique role in identifying morphologic abnormalities of various fibers, fibrils, and filaments, and helping to localize biochemical constituents to these structures in epidermolysis bullosa.
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Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus
Noritaka Oyama,Ien Chan,Sallie Neill,Andrew P. South,Fenella Wojnarowska,Yoshio Kawakami,David D'Cruz,Kirti Mepani,Graham J. Hughes,Balbir S. Bhogal,Fumio Kaneko,Martin M. Black,John A. McGrath +12 more
TL;DR: High anti-ECM1 titers correlated with more longstanding and refractory disease and cases complicated by squamous cell carcinoma, and passive transfer of affinity-purified patient IgG reproduced some histologic and immunopathologic features of lichen sclerosus skin.