J
John A. McGrath
Researcher at King's College London
Publications - 674
Citations - 26684
John A. McGrath is an academic researcher from King's College London. The author has contributed to research in topics: Epidermolysis bullosa & Mutation. The author has an hindex of 75, co-authored 631 publications receiving 24078 citations. Previous affiliations of John A. McGrath include Ninewells Hospital & Southampton General Hospital.
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Journal ArticleDOI
Alterations in desmosome size and number coincide with the loss of keratinocyte cohesion in skin with homozygous and heterozygous defects in the desmosomal protein plakophilin 1
James R. McMillan,Marek Haftek,Masashi Akiyama,Andrew P. South,Henri Perrot,John A. McGrath,Robin A.J. Eady,Hiroshi Shimizu +7 more
TL;DR: Findings attest to the molecular recruiting and stabilizing roles of PkP1 in desmosome formation, particularly in the LSB compartment, despite only PKP1 null patients exhibiting any phenotype.
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Thalidomide in the management of epidermolysis bullosa pruriginosa.
S. Ozanic Bulic,Hiva Fassihi,Jemima E. Mellerio,Jemima E. Mellerio,John A. McGrath,David J. Atherton +5 more
TL;DR: A patient with dominant dystrophic EB pruriginosa, who had an excellent response to systemic thalidomide treatment is reported, who may suppress excessive production of tumour necrosis factor‐α and may downregulate certain cell surface adhesion molecules involved in leucocyte migration.
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Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts
Chao Kai Hsu,Hsi Hui Lin,Hans I.Chen Harn,Rei Ogawa,Yang Kao Wang,Yen Ting Ho,Wan Rung Chen,Yi Chao Lee,Julia Yu-Yun Lee,Shyh Jou Shieh,Chao-Min Cheng,John A. McGrath,Ming Jer Tang +12 more
TL;DR: A role for CAV1 down-regulation is suggested in linking the aberrant responsiveness to mechanical stimulation and extracellular matrix accumulation with the progression of keloids, findings that may lead to new developments in the prevention and treatment of keLoid scarring.
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Transplanted Bone Marrow–Derived Circulating PDGFRα+ Cells Restore Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa Mouse Skin Graft
Shin Iinuma,Eriko Aikawa,Katsuto Tamai,Ryo Fujita,Yasushi Kikuchi,Takenao Chino,Junichi Kikuta,John A. McGrath,Jouni Uitto,Masaru Ishii,Hajime Iizuka,Yasufumi Kaneda +11 more
TL;DR: Data suggest that the SDF1α/CXCR4 signaling axis induces transplanted bone marrow–derived circulating PDGFRα+ mesenchymal cells to migrate and supply functional Col7 to regenerate RDEB skin.
Journal ArticleDOI
Recessive epidermolysis bullosa simplex associated with plectin mutations: infantile respiratory complications in two unrelated cases.
Jemima E. Mellerio,Fjd Smith,James R. McMillan,Whi McLean,John A. McGrath,G. A. J. Morrison,P. Tierney,D. M. Albert,Gerhard Wiche,Irene M. Leigh,J.F. Geddes,E. B. Lane,Jouni Uitto,Robin A.J. Eady +13 more
TL;DR: Two unrelated patients, both of consanguineous parentage, who presented with cutaneous blistering and a hoarseness and stridor in infancy are reported, and the identification of mutations in PLEC1 may be predictive for the future development of muscular dystrophy.