J
John A. McGrath
Researcher at King's College London
Publications - 674
Citations - 26684
John A. McGrath is an academic researcher from King's College London. The author has contributed to research in topics: Epidermolysis bullosa & Mutation. The author has an hindex of 75, co-authored 631 publications receiving 24078 citations. Previous affiliations of John A. McGrath include Ninewells Hospital & Southampton General Hospital.
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Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting
Liat Samuelov,Ofer Sarig,Robert M. Harmon,Debora Rapaport,Akemi Ishida-Yamamoto,Ofer Isakov,Jennifer L. Koetsier,Andrea Gat,Ilan Goldberg,Reuven Bergman,Reuven Bergman,Ronen Spiegel,O. Eytan,O. Eytan,Shamir Geller,Sarit Peleg,Noam Shomron,Christabelle S M Goh,Neil J. Wilson,Frances J.D. Smith,Elizabeth Pohler,Michael A. Simpson,W.H. Irwin McLean,Alan D. Irvine,Alan D. Irvine,Mia Horowitz,John A. McGrath,Kathleen J. Green,Eli Sprecher,Eli Sprecher +29 more
TL;DR: The deciphering of the pathogenesis of SAM syndrome substantiates the notion that allergy may result from a primary structural epidermal defect and is linked to a number of genes encoding allergy-related cytokines.
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Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1)
Takahiro Hamada,W.H. Irwin McLean,Michèle Ramsay,G. H. S. Ashton,Arti Nanda,Trefor Jenkins,Isobel Edelstein,Andrew P. South,Oliver Bleck,Vesarat Wessagowit,R. Mallipeddi,Guy Orchard,Hong Wan,Patricia J.C. Dopping-Hepenstal,Jemima E. Mellerio,Neil V. Whittock,Colin S. Munro,Maurice A.M. van Steensel,Peter M. Steijlen,Jian Ni,Lurong Zhang,Takashi Hashimoto,Robin A.J. Eady,John A. McGrath +23 more
TL;DR: These findings provide the first clinical indication of its relevance to skin adhesion, epidermal differentiation, wound healing, scarring, angiogenesis/angiopathy and basement membrane physiology, as well as defining the molecular basis of this inherited disorder.
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A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome
Elena Maestrini,Anthony P. Monaco,John A. McGrath,Akemi Ishida-Yamamoto,Charles Camisa,Alain Hovnanian,Daniel E. Weeks,Daniel E. Weeks,Mark Lathrop,Jouni Uitto,Angela M. Christiano +10 more
TL;DR: In this article, an insertion that shifts the translation frame of the C-terminal Gly-and Gln/Lys-rich domains of the loricrin gene was found to impair cornification.
Journal Article
Antigen-specific ELISA for detection of circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus
Noritaka Oyama,Ien Chan,Sarah Neill,Andrew P. South,Fumio Kaneko,Martin M. Black,Fenella Wojnarowska,John A. McGrath +7 more
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Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa.
T Wong,Luke Gammon,Lu Liu,Jemima E. Mellerio,Patricia J.C. Dopping-Hepenstal,John Pacy,George Elia,Rosemary Jeffery,Irene M. Leigh,Harshad Navsaria,John A. McGrath +10 more
TL;DR: This is the first study demonstrating that intradermal injections of allogeneic fibroblasts have therapeutic potential in human subjects with RDEB, and it is believed that this mutant protein may be partially functional and capable of increasing adhesion at the DEJ.