J
John B. Stokes
Researcher at University of Iowa
Publications - 116
Citations - 7847
John B. Stokes is an academic researcher from University of Iowa. The author has contributed to research in topics: Epithelial sodium channel & Aldosterone. The author has an hindex of 45, co-authored 116 publications receiving 7445 citations. Previous affiliations of John B. Stokes include Yale University & Max Planck Society.
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Journal ArticleDOI
Intensity of renal support in critically ill patients with acute kidney injury
Paul M. Palevsky,Jane Hongyuan Zhang,Theresa Z. O'Connor,Glenn M. Chertow,Susan T. Crowley,Devasmita Choudhury,Kevin W. Finkel,John A. Kellum,Emil P. Paganini,Roland M. H. Schein,Mark W. Smith,Kathleen M. Swanson,B. Taylor Thompson,Anitha Vijayan,Suzanne Watnick,Robert A. Star,Peter Peduzzi,E. Young,R. Fissel,W. Fissel,Uptal D. Patel,K. Belanger,A. Raine,N. Ricci,James B. Lohr,P. Arora,D. Cloen,D. Wassel,L. Yohe,J. Amanzadeh,J. Penfield,M. Hussain,R. Katneni,A. Sajgure,A. Swann,G. Dolson,V. Ramanathan,G. Tasby,Robert L. Bacallao,M. Jaradat,Kenneth Edward Graves,Q. Li,M. Krause,M. Shaver,M. Alam,K. Morris,T. Bland,E. Satter,Jeffrey A. Kraut,A. Felsenfeld,B. Levine,G. Nagami,B. Vaghaiwalla,J. Duffney,Joseph O. Moore,C. Cely,E. Jaimes,Daniel H. Kett,Andrew A. Quartin,M. Arcia,A. Barchi-Chung,Vecihi Batuman,A. Alper,A. Dreisbach,E. Simon,C. Kulivan,Nabeel Aslam,M.C. Ramkumar,E. Grum,P. Rogers,Steven D. Weisbord,C. Geffel,Ihab M. Wahba,Darren J. Kelly,J. Walczyk,George Feldman,A. Mogyorosi,G. Viol,M. Halverson,S. Schmid,H. Totten,Francis B. Gabbai,S. Mullaney,R. Smith,J. Dingsdale,S. Woods,Kirsten L. Johansen,David H. Lovett,Ann M. O’Hare,James T. McCarthy,C. Rosado-Rodriguez,A. Galera,G. Rodriguez-Vega,W. Rodriguez,C. Vilchez,B. Young,Dennis L. Andress,A. Lindner,G. Galvin,N. Gourley,Aldo J. Peixoto,M. Perkal,C. Joncas,Sevag Demirjian,J. Yared,R. Brienza,M. Garcia,T. Seifert,L. Sweeney,Hamid Rabb,Mohamed G. Atta,Roy G. Brower,M. Choi,Joseph A. Eustace,Paul J. Scheel,E. Heck,H. Rahman,John L. Niles,H. Bazari,K. Smirnakis,D. Steele,Ravi Thadhani,K. Laliberte,B. Leeman,C. McCarthy,M. Pescatore,Harold M. Szerlip,P. Fall,M. Jagadeesan,Laura L Mulloy,William D Paulson,J. White,N. Sickafoose,K. Cho,M. Gropper,K. Liu,Michael A. Matthay,K. Borovitz,M. Koenigsberg,S. Rodriguez,Gabriel Contreras,S. Cohn,J. Diego,C. Carvalho,D. Carvalho,M. Castro,C. de la Cuesta,I. Espinal,A. Hurtado,P. Oyuela,Mark Unruh,Renee Burr,Michael P. Donahoe,J. Marszalek,M. Shields,R. Venkataraman,J. Aubrecht,H. Sterling,L. Mandich,A. Shaw,J. Foringer,J. Samuels,B. Efron,Michael V. Rocco,E. Deterding,Shahriar Moossavi,C. Bethea,D. McBride,Stuart R. Warren,M. Kollef,K. Sambandam,E. Hammer,M. Hoffman,John B. Stokes,Alfred F. Connors,Harold I. Feldman,Joel W. Greer,G. G. Koch,Thomas E. Stewart,Janet Wittes,P. Overberger,S. Michler,Massimo Antonelli,K. Dellert,L. Durant,R. Franchini,A. Kossack,V. McBride,S. O'Neil,Taposh Roy,J. Russo,Joseph N. Vitale,Mike R. Sather,C. Fye,C. M. Haakenson,D. H. Krueger,J. Thornton,C. Dalzell,R. Horney,Andrew M. Siroka,P. Su,Mary Brophy,D. Humphries,D. Govan,Timothy J. O'Leary,G. D. Huang,John R. Feussner,Paul W. Eggers +207 more
TL;DR: Intensive renal support in critically ill patients with acute kidney injury did not decrease mortality, improve recovery of kidney function, or reduce the rate of nonrenal organ failure as compared with less-intensive therapy.
Journal ArticleDOI
The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial
Michael V. Rocco,Robert S. Lockridge,Gerald J. Beck,Paul W. Eggers,Jennifer J. Gassman,Tom Greene,Brett Larive,Christopher T. Chan,Glenn M. Chertow,Glenn M. Chertow,Michael Copland,Christopher D. Hoy,Robert M. Lindsay,Nathan W. Levin,Daniel B. Ornt,Andreas Pierratos,Mary Pipkin,Sanjay Rajagopalan,John B. Stokes,Mark Unruh,Robert A. Star,Alan S. Kliger +21 more
TL;DR: Patients in the nocturnal arm had improved control of hyperphosphatemia and hypertension, but no significant benefit among the other main secondary outcomes.
Journal ArticleDOI
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na^+ channel
Peter M. Snyder,Margaret P. Price,Fiona J. McDonald,Christopher M. Adams,Kenneth A. Volk,Bernhardt G. Zeiher,John B. Stokes,Michael J. Welsh +7 more
TL;DR: By deleting a conserved motif, Liddle's mutations increase the number of Na+ channels in the apical membrane, which increases renal Na+ absorption and creates a predisposition to hypertension.
Journal ArticleDOI
Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype.
Fiona J. McDonald,Baoli Yang,Ron F. Hrstka,Heather A. Drummond,Deirdre E. Tarr,Paul B. McCray,John B. Stokes,Michael J. Welsh,Roger A. Williamson +8 more
TL;DR: The results indicate that, in vivo, the beta subunit is required for ENaC function in the renal collecting duct, but, in contrast to the alpha subunit, thebeta sub unit is not required for the transition from a liquid-filled to an air-filled lung.
Journal ArticleDOI
Membrane topology of the amiloride-sensitive epithelial sodium channel.
TL;DR: A model of alpha rENaC consisting of an intracellular N terminus and C terminus, a large N-glycosylated extracellular domain, and two membrane-spanning domains that each pass once through the plasma membrane is supported.