J
John Bechhoefer
Researcher at Simon Fraser University
Publications - 139
Citations - 8411
John Bechhoefer is an academic researcher from Simon Fraser University. The author has contributed to research in topics: DNA replication & Liquid crystal. The author has an hindex of 36, co-authored 133 publications receiving 7487 citations. Previous affiliations of John Bechhoefer include University of Chicago & University of British Columbia.
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Hidden Markov models for stochastic thermodynamics
TL;DR: In this paper, the authors use the HMM formalism to shed light on a recent discussion of phase transitions in the optimized response of an information engine, for which measurement noise serves as a control parameter.
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Control of DNA replication by anomalous reaction-diffusion kinetics.
TL;DR: In this article, a simple model for the control of DNA replication in which the rate of initiation of replication origins is controlled by protein-DNA interactions was proposed, and it was shown that the interaction between DNA and the rate-limiting protein must be subdiffusive.
Journal ArticleDOI
Inferring where and when replication initiates from genome-wide replication timing data.
Antoine Baker,Benjamin Audit,Benjamin Audit,Scott Cheng-Hsin Yang,John Bechhoefer,Alain Arneodo +5 more
TL;DR: This work shows how to invert analytically the Kolmogorov-Johnson-Mehl-Avrami model and extract I(x,t) directly from genome-wide replication timing data and confirms the location and firing-time distribution of replication origins.
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Test of the diffusing-diffusivity mechanism using near-wall colloidal dynamics.
TL;DR: Single-particle tracking measurements of the diffusion of colloidal spheres near a planar substrate are reported, showing that, in environments where the diffusivity changes gradually, the displacement distribution becomes non-Gaussian, even though the mean-square displacement grows linearly with time.
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Real-Time Calibration of a Feedback Trap
TL;DR: It is shown that a recursive maximum likelihood (RML) algorithm can allow real-time measurement and control of electric and stochastic forces over time scales of hours.