Claire W. Hallahan

TL;DR: The course of Wegener granulomatosis has been dramatically improved by daily treatment with cyclophosphamide and glucocorticoids, and has led to increasing concerns about toxicity resulting from prolonged cycloph phosphamide therapy and has encouraged investigation of other therapeutic regimens.

TL;DR: Results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function, and the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.

TL;DR: These results establish an effector function and mechanism that clearly segregate with immunologic control of HIV and demonstrate that lytic granule contents of memory cells are a critical determinant of cytotoxicity that must be induced for maximal per-cell killing capacity.

TL;DR: It is suggested that the GALT may play a major role in the persistence of HIV in such individuals who had been receiving effective antiviral therapy for prolonged periods of time, and a possible mechanism for the maintenance of viral reservoirs revolving around the Galt of HIV-infected individuals despite long-term viral suppression is provided.

TL;DR: The incidence, clinical manifestations, and natural history of cyclophosphamide-mediated urotoxicity in a cohort of patients with Wegener granulomatosis are described and recommendations for surveillance are discussed.