Mark Dybul

TL;DR: The findings show that HIV-specific CD4+ T cells are preferentially infected by HIV in vivo, which provides a potential mechanism to explain the loss of HIV- specific CD4- T-cell responses, and consequently theloss of immunological control of HIV replication.

TL;DR: This report provides pathogenesis-based rationale for therapeutic strategies as well as guidelines for implementing these strategies and recommends that, when possible, the treatment of HIV-infected patients should be directed by a clinician who has extensive experience in the care of these patients.

TL;DR: Results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV.

TL;DR: It is shown that recombinant envelope proteins from macrophage-tropic HIV and SIV induce a signal through CCR5 on CD4+ T cells and that envelope-mediated signal transduction through C CR5 induces chemotaxis of T cells.

TL;DR: It is demonstrated that altered expression of genes associated with IFN stimulation and terminal differentiation in B cells of HIV-viremic patients lead to an increased propensity to cell death, which may have substantial deleterious effects on B cell responsiveness to antigenic stimulation.