J
John J. Sauk
Researcher at University of Louisville
Publications - 177
Citations - 7011
John J. Sauk is an academic researcher from University of Louisville. The author has contributed to research in topics: Cell culture & Epidermoid carcinoma. The author has an hindex of 46, co-authored 176 publications receiving 6745 citations. Previous affiliations of John J. Sauk include University of Michigan & Great Lakes Institute of Management.
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Journal ArticleDOI
Dentin Sialophosphoprotein Knockout Mouse Teeth Display Widened Predentin Zone and Develop Defective Dentin Mineralization Similar to Human Dentinogenesis Imperfecta Type III
Taduru Sreenath,Tamizchelvi Thyagarajan,Bradford Hall,Glenn Longenecker,Rena N. D'Souza,Sung Hong,J. Tim Wright,Mary MacDougall,John J. Sauk,Ashok B. Kulkarni +9 more
TL;DR: The generation of Dspp-null mice that develop tooth defects similar to human dentinogenesis imperfecta III with enlarged pulp chambers, increased width of predentin zone, hypomineralization, and pulp exposure are reported.
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High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma
TL;DR: It is reported that HMGA2 expression in head and neck squamous cell carcinoma (HNSCC) cells is regulated in part by miRNA-98 (miR-98), and the demonstration that miRNA profiles are altered during hypoxia and repress a genotoxic response indicates that changes in microenvironment in eukaryotes mimic those of lower species and plants.
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Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
Panomwat Amornphimoltham,Vyomesh Patel,Akrit Sodhi,Nikolaos G. Nikitakis,John J. Sauk,Edward A. Sausville,Alfredo A. Molinolo,J. Silvio Gutkind +7 more
TL;DR: The Akt-mTOR pathway is identified as a potential therapeutic target for HNSCC, and may provide the rationale for the early clinical evaluation of rapamycin and its analogues in patients with HNS CC.
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Human Periodontal Cells Initiate Mineral-Like Nodules In Vitro
TL;DR: Differences in behavior between PDL cells and gingival fibroblasts may prove important in designing appropriate clinical therapies directed at stimulating periodontal regeneration.
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Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
Panomwat Amornphimoltham,Virote Sriuranpong,Vyomesh Patel,Fernando Benavides,Claudio J. Conti,John J. Sauk,Edward A. Sausville,Alfredo A. Molinolo,J. Silvio Gutkind +8 more
TL;DR: Evidence is provided that the Akt signaling pathway may represent a biologically relevant target for a novel antineoplastic agent, UCN-01, which recently has been shown to be active in cellular and xenograft models for HNSCC at concentrations safely achievable in clinically relevant situations.