M
Mary MacDougall
Researcher at University of Alabama at Birmingham
Publications - 139
Citations - 7387
Mary MacDougall is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Odontoblast & Dentin sialophosphoprotein. The author has an hindex of 45, co-authored 137 publications receiving 6871 citations. Previous affiliations of Mary MacDougall include University of Texas at San Antonio & University of Texas at Austin.
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Journal ArticleDOI
Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4 : dentin phosphoprotein dna sequence determination
TL;DR: The data suggest that the previously identified dentin extracellular matrix proteins, dentin sialoprotein and dentin phosphoprotein, are expressed as a single cDNA transcript coding for a protein that is specifically cleaved into two smaller polypeptides with unique physical-chemical characteristics.
Journal ArticleDOI
Isolation and characterization of multipotent human periodontal ligament stem cells
Shuo Chen,Mary MacDougall +1 more
TL;DR: The PDL contains SC that have the potential to differentiate into osteoblasts, chondrocytes and adipocytes, comparable with previously characterized BMSC, and can be utilized for potential therapeutic procedures related to PDL regeneration.
Journal ArticleDOI
Dentin Sialophosphoprotein Knockout Mouse Teeth Display Widened Predentin Zone and Develop Defective Dentin Mineralization Similar to Human Dentinogenesis Imperfecta Type III
Taduru Sreenath,Tamizchelvi Thyagarajan,Bradford Hall,Glenn Longenecker,Rena N. D'Souza,Sung Hong,J. Tim Wright,Mary MacDougall,John J. Sauk,Ashok B. Kulkarni +9 more
TL;DR: The generation of Dspp-null mice that develop tooth defects similar to human dentinogenesis imperfecta III with enlarged pulp chambers, increased width of predentin zone, hypomineralization, and pulp exposure are reported.
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Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo
Rena N. D'Souza,Adriana Cavender,G. Sunavala,J. Alvarez,Toshio Ohshima,Ashok B. Kulkarni,Mary MacDougall +6 more
TL;DR: The in vivo temporospatial expression patterns of two dentin NCP genes, dentin matrix protein 1 (Dmp1), and dentin sialophosphoprotein (DSPP) in developing molars are compared, implying that these molecules serve different biological functions in vivo.
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Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development.
Ling Ye,Mary MacDougall,Shubin Zhang,Yixia Xie,Jianghong Zhang,Zubing Li,Yongbo Lu,Yuji Mishina,Jian Q. Feng +8 more
TL;DR: It is shown that Dmp-1 null mice postnatally develop a profound tooth phenotype characterized by a partial failure of maturation ofpredentin into dentin, enlarged pulp chambers, increased width of predentin zone with reduced dentin wall, and hypomineralization, which suggests that DMP-1 is essential for later dentinogenesis during postnatal development.