J
John M. Coffin
Researcher at Tufts University
Publications - 339
Citations - 31956
John M. Coffin is an academic researcher from Tufts University. The author has contributed to research in topics: Virus & Provirus. The author has an hindex of 96, co-authored 338 publications receiving 30228 citations. Previous affiliations of John M. Coffin include Case Western Reserve University & Tufts Medical Center.
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HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy
TL;DR: Results lead to a simple steady-state model in which infection, cell death, and cell replacement are in balance, and imply that the unique feature of HIV is the extraordinarily large number of replication cycles that occur during infection of a single individual.
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Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
Nancie M. Archin,Abigail L. Liberty,Angela D. M. Kashuba,Shailesh K. Choudhary,Joann D. Kuruc,Amanda M. Crooks,Daniel C. Parker,Elizabeth M. Anderson,Mary F. Kearney,Matthew C. Strain,Douglas D. Richman,Michael G. Hudgens,Ronald J. Bosch,John M. Coffin,Joseph J. Eron,Daria J. Hazuda,David M. Margolis +16 more
TL;DR: It is demonstrated that a molecular mechanism known to enforce HIV latency can be therapeutically targeted in humans, provides proof-of-concept for histone deacetylase inhibitors as a therapeutic class, and defines a precise approach to test novel strategies to attack and eradicate latent HIV infection directly.
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Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Frank Maldarelli,Xiaolin Wu,Ling Su,Francesco R. Simonetti,Wei Shao,Shawn Hill,Jonathan Spindler,A. L. Ferris,John W. Mellors,Mary F. Kearney,John M. Coffin,Stephen H. Hughes +11 more
TL;DR: Findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells, and may determine the size of the latent reservoir.
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Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
Sarah Palmer,Frank Maldarelli,Ann Wiegand,Barry Bernstein,George J. Hanna,Scott C. Brun,Dale J. Kempf,John W. Mellors,John M. Coffin,Martin S. King +9 more
TL;DR: Analysis of longitudinal plasma samples from 40 patients enrolled in the Abbott M97-720 trial suggests that low-level persistent viremia appears to arise from at least two cell compartments, one in which viral production decays over time and a second inWhich viral production remains stable for at least 7 years.
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Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome.
Qin Yu,Renate König,Satish K. Pillai,Kristopher Chiles,Mary F. Kearney,Sarah Palmer,Douglas D. Richman,Douglas D. Richman,John M. Coffin,Nathaniel R. Landau +9 more
TL;DR: It is reported here that minus-strand deamination occurred over the length of the virus genome, preferentially at CCCA sequences, with a graded frequency in the 5′→3′ direction.