Frank Maldarelli

TL;DR: Findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells, and may determine the size of the latent reservoir.

TL;DR: Analysis of longitudinal plasma samples from 40 patients enrolled in the Abbott M97-720 trial suggests that low-level persistent viremia appears to arise from at least two cell compartments, one in which viral production decays over time and a second inWhich viral production remains stable for at least 7 years.

TL;DR: An internally controlled real-time reverse transcriptase-initiated PCR assay that quantifies HIV-1 RNA concentrations down to 1 copy per ml of plasma and had a greater sensitivity than the other assays shown, allowing better characterization of persistent viremia in patients who are receiving antiretroviral therapy and whose HIV- 1 RNA levels are suppressed to below the detection limits of present assays.

TL;DR: It is demonstrated that the presence of the HIV-1-encoded integral membrane protein Vpu can reduce the formation of Env-CD4 complexes, resulting in increased gp160 processing and decreased CD4 stability.

TL;DR: The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure and several priorities for basic, translational and clinical research were identified.