Sarah Palmer

TL;DR: Analysis of longitudinal plasma samples from 40 patients enrolled in the Abbott M97-720 trial suggests that low-level persistent viremia appears to arise from at least two cell compartments, one in which viral production decays over time and a second inWhich viral production remains stable for at least 7 years.

TL;DR: It is reported here that minus-strand deamination occurred over the length of the virus genome, preferentially at CCCA sequences, with a graded frequency in the 5′→3′ direction.

TL;DR: An internally controlled real-time reverse transcriptase-initiated PCR assay that quantifies HIV-1 RNA concentrations down to 1 copy per ml of plasma and had a greater sensitivity than the other assays shown, allowing better characterization of persistent viremia in patients who are receiving antiretroviral therapy and whose HIV- 1 RNA levels are suppressed to below the detection limits of present assays.

TL;DR: The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure and several priorities for basic, translational and clinical research were identified.

TL;DR: Results suggest that, despite suppressive HAART, active replication persists in some infected individuals and drives immune activation, and the ability of raltegravir intensification to perturb the reservoir that supports active replication has implications for therapeutic strategies aimed at achieving viral eradication.