M
Matthew C. Strain
Researcher at University of California, San Diego
Publications - 41
Citations - 6373
Matthew C. Strain is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Viral load & Virus. The author has an hindex of 30, co-authored 41 publications receiving 5820 citations. Previous affiliations of Matthew C. Strain include Veterans Health Administration & University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
Nancie M. Archin,Abigail L. Liberty,Angela D. M. Kashuba,Shailesh K. Choudhary,Joann D. Kuruc,Amanda M. Crooks,Daniel C. Parker,Elizabeth M. Anderson,Mary F. Kearney,Matthew C. Strain,Douglas D. Richman,Michael G. Hudgens,Ronald J. Bosch,John M. Coffin,Joseph J. Eron,Daria J. Hazuda,David M. Margolis +16 more
TL;DR: It is demonstrated that a molecular mechanism known to enforce HIV latency can be therapeutically targeted in humans, provides proof-of-concept for histone deacetylase inhibitors as a therapeutic class, and defines a precise approach to test novel strategies to attack and eradicate latent HIV infection directly.
Journal ArticleDOI
Defective proviruses rapidly accumulate during acute HIV-1 infection.
Katherine M. Bruner,Alexandra J. Murray,Ross A. Pollack,Mary Soliman,Sarah B. Laskey,Adam A. Capoferri,Adam A. Capoferri,Jun Lai,Matthew C. Strain,Steven M. Lada,Rebecca Hoh,Ya Chi Ho,Douglas D. Richman,Douglas D. Richman,Steven G. Deeks,Janet D. Siliciano,Robert F. Siliciano,Robert F. Siliciano +17 more
TL;DR: It is demonstrated that early initiation of ART limits the size of the reservoir but does not profoundly affect the proviral landscape, and hurdles that must be overcome are revealed to successfully analyze future HIV-1 cure strategies.
Journal ArticleDOI
Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant
Deborah Persaud,Carrie Ziemniak,Ya Hui Chen,Michael Piatak,Tae Wook Chun,Matthew C. Strain,Matthew C. Strain,Douglas D. Richman,Douglas D. Richman,Katherine Luzuriaga +9 more
TL;DR: The case of an infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy 30 hours after birth suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.
Journal ArticleDOI
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies
Susanne Eriksson,Erin H. Graf,Viktor Dahl,Matthew C. Strain,Steven A. Yukl,Steven A. Yukl,Elena S. Lysenko,Ronald J. Bosch,Jun Lai,Stanley Chioma,Fatemeh Emad,Mohamed Abdel-Mohsen,Rebecca Hoh,Frederick Hecht,Peter W. Hunt,Ma Somsouk,Joseph K. Wong,Joseph K. Wong,Rowena Johnston,Robert F. Siliciano,Robert F. Siliciano,Douglas D. Richman,Una O'Doherty,Sarah Palmer,Steven G. Deeks,Janet D. Siliciano,Janet D. Siliciano +26 more
TL;DR: Eleven different approaches are compared for quantitating persistent HIV-1 in 30 patients on HAART, using the original viral outgrowth assay for resting CD4+ T cells carrying inducible, replication-competent viral genomes as a standard for comparison.
Journal ArticleDOI
Highly precise measurement of HIV DNA by droplet digital PCR.
Matthew C. Strain,Steven M. Lada,Steven M. Lada,Tiffany Q. Luong,Tiffany Q. Luong,Steffney E. Rought,Steffney E. Rought,Sara Gianella,Sara Gianella,Valeri H. Terry,Valeri H. Terry,Celsa A. Spina,Celsa A. Spina,Christopher H. Woelk,Christopher H. Woelk,Douglas D. Richman,Douglas D. Richman +16 more
TL;DR: Analysis of over 300 clinical samples demonstrates a significant increase in precision, with an average 5-fold decrease in the coefficient of variation of pol copy numbers and a >20-fold accuracy improvement for 2-LTR circles.