L
Luke Boulter
Researcher at University of Edinburgh
Publications - 59
Citations - 5107
Luke Boulter is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Liver regeneration & Progenitor cell. The author has an hindex of 21, co-authored 47 publications receiving 3500 citations. Previous affiliations of Luke Boulter include Western General Hospital & Medical Research Council.
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Journal ArticleDOI
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Jesus M. Banales,Jesus M. Banales,Jesus M. Banales,Jose J.G. Marin,Jose J.G. Marin,Angela Lamarca,Angela Lamarca,Pedro M. Rodrigues,Shahid A. Khan,Lewis R. Roberts,Vincenzo Cardinale,Guido Carpino,Jesper B. Andersen,Chiara Braconi,Diego F. Calvisi,Maria J. Perugorria,Maria J. Perugorria,Luca Fabris,Luca Fabris,Luke Boulter,Rocio I.R. Macias,Rocio I.R. Macias,Eugenio Gaudio,Domenico Alvaro,Sergio A. Gradilone,Mario Strazzabosco,Mario Strazzabosco,Marco Marzioni,Cédric Coulouarn,Laura Fouassier,Chiara Raggi,Pietro Invernizzi,Joachim C. Mertens,Anja Moncsek,Sumera Rizvi,Julie K. Heimbach,Bas Groot Koerkamp,Jordi Bruix,Jordi Bruix,Alejandro Forner,Alejandro Forner,John Bridgewater,Juan W. Valle,Juan W. Valle,Gregory J. Gores +44 more
TL;DR: This expert Consensus Statement, endorsed by the ENS-CCA, summarizes the latest advances in CCA, including classification, genetics and treatment, and provides recommendations for CCA management and priorities across basic, translational and clinical research.
Journal ArticleDOI
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran,Antonella Pellicoro,Madeleine A. Vernon,Luke Boulter,Rebecca L. Aucott,Aysha Ali,Stephen N. Hartland,Victoria K. Snowdon,Andrea Cappon,Timothy T. Gordon-Walker,Mike J. Williams,Donald R. Dunbar,Jonathan R. Manning,Nico van Rooijen,Jonathan A. Fallowfield,Stuart J. Forbes,John P. Iredale +16 more
TL;DR: The restorative macrophage phenotype was recapitulated in vitro by the phagocytosis of cellular debris with associated activation of the ERK signaling cascade, offering a therapeutic strategy to this orphan pathological process.
Journal ArticleDOI
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.
Luke Boulter,Olivier Govaere,Thomas G. Bird,Sorina Radulescu,Prakash Ramachandran,Antonella Pellicoro,Rachel A. Ridgway,Sang Soo Seo,Bart Spee,Nico Van Rooijen,Nico Van Rooijen,Owen J. Sansom,John P. Iredale,Sally Lowell,Tania Roskams,Stuart J. Forbes +15 more
TL;DR: It is found that during biliary regeneration, expression of Jagged 1 by myofibroblasts promoted Notch signaling in HPCs and thus their biliary specification to cholangiocytes and thus the promotion of their specification to hepatocytes.
Journal ArticleDOI
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Wei-Yu Lu,Thomas G. Bird,Luke Boulter,Atsunori Tsuchiya,Alicia M. Cole,Trevor Hay,Rachel V. Guest,Davina Wojtacha,Tak Yung Man,Alison C. MacKinnon,Rachel A. Ridgway,Timothy J. Kendall,Michael Williams,Thomas Jamieson,Alex Raven,David C. Hay,John P. Iredale,Alan Richard Clarke,Owen J. Sansom,Stuart J. Forbes +19 more
TL;DR: A mouse model where the E3 ubiquitin ligase Mdm2 is inducibly deleted in more than 98% of hepatocytes, causing apoptosis, necrosis and senescence with nearly all hepatocytes expressing p21 is described, resulting in florid HPC activation, which is necessary for survival, followed by complete, functional liver reconstitution.
Journal ArticleDOI
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
Alexander Raven,Wei-Yu Lu,Tak Yung Man,Sofia Ferreira-Gonzalez,Eoghan O'Duibhir,Benjamin J. Dwyer,John P. Thomson,Richard R. Meehan,Roman L. Bogorad,Victor Koteliansky,Yuri Kotelevtsev,Charles ffrench-Constant,Luke Boulter,Stuart J. Forbes +13 more
TL;DR: A model of combined liver injury and inhibition of hepatocyte proliferation that causes physiologically significant levels of regeneration of functional hepatocytes from biliary cells is described.