J
John P. Reilly
Researcher at University of Pennsylvania
Publications - 55
Citations - 3145
John P. Reilly is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: ARDS & Sepsis. The author has an hindex of 22, co-authored 55 publications receiving 1795 citations. Previous affiliations of John P. Reilly include University of Georgia & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Divij Mathew,Josephine R. Giles,Amy E. Baxter,Derek A. Oldridge,Allison R. Greenplate,Jennifer E. Wu,Cécile Alanio,Leticia Kuri-Cervantes,M. Betina Pampena,Kurt D'Andrea,Sasikanth Manne,Zeyu Chen,Yinghui Jane Huang,John P. Reilly,Ariel R. Weisman,Caroline A. G. Ittner,Oliva Kuthuru,Jeanette Dougherty,Kito Nzingha,Nicholas Han,Justin Kim,Ajinkya Pattekar,Eileen C. Goodwin,Elizabeth M. Anderson,Madison E. Weirick,Sigrid Gouma,Claudia P. Arevalo,Marcus J. Bolton,Fang Chen,Simon F. Lacey,Holly Ramage,Sara Cherry,Scott E. Hensley,Sokratis A. Apostolidis,Alexander C. Huang,Laura A. Vella,Laura A. Vella,Michael R. Betts,Nuala J. Meyer,E. John Wherry +39 more
TL;DR: High-dimensional flow cytometry of hospitalized COVID-19 patients found three prominent and distinct immunotypes that are related to disease severity and clinical parameters, and a compendium of immune cell information and roadmaps for potential therapeutic interventions is provided.
Journal ArticleDOI
CD8 + T cells contribute to survival in patients with COVID-19 and hematologic cancer.
Erin Bange,Nicholas Han,Paul Wileyto,Justin Kim,Sigrid Gouma,James Robinson,Allison R. Greenplate,Madeline A Hwee,Florence Porterfield,Olutosin Owoyemi,Karan Naik,Cathy Zheng,Michael Galantino,Ariel R. Weisman,Caroline A. G. Ittner,Emily M. Kugler,Amy E. Baxter,Olutwatosin Oniyide,R.S. Agyekum,Thomas G. Dunn,Tiffanie K. Jones,Heather M. Giannini,Madison E. Weirick,Christopher M McAllister,N. Esther Babady,Anita Kumar,Adam J Widman,Susan DeWolf,Sawsan R. Boutemine,Charlotte Roberts,Krista R Budzik,Susan Tollett,Carla Wright,Tara Perloff,Lova Sun,Divij Mathew,Josephine R. Giles,Derek A. Oldridge,Jennifer E. Wu,Cécile Alanio,Sharon Adamski,Alfred L. Garfall,Laura A. Vella,Samuel J Kerr,Samuel J Kerr,Justine V. Cohen,Randall A. Oyer,Randall A. Oyer,Ryan Massa,Ivan Maillard,Kara N. Maxwell,John P. Reilly,Peter Maslak,Robert H. Vonderheide,Jedd D. Wolchok,Scott E. Hensley,E. John Wherry,Nuala J. Meyer,Angela DeMichele,Santosha Vardhana,Ronac Mamtani,Alexander C. Huang +61 more
TL;DR: In this paper, the authors showed that CD8 T cell responses to vaccination might provide protection in patients with hematologic cancer even in the setting of limited humoral responses, including those treated with anti-CD20 therapy.
Posted ContentDOI
Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
Divij Mathew,Josephine R. Giles,Amy E. Baxter,Allison R. Greenplate,Jennifer E. Wu,Cécile Alanio,Derek A. Oldridge,Leticia Kuri-Cervantes,M. Betina Pampena,Sasikanth Manne,Zeyu Chen,Yinghui Jane Huang,John P. Reilly,Ariel R. Weisman,Caroline A. G. Ittner,Oliva Kuthuru,Jeanette Dougherty,Kito Nzingha,Nicholas Han,Justin Kim,Ajinkya Pattekar,Eileen C. Goodwin,Elizabeth M. Anderson,Madison E. Weirick,Sigrid Gouma,Claudia P. Arevalo,Marcus J. Bolton,Fang Chen,Simone F Lacey,Scott E. Hensley,Sokratis A. Apostolidis,Alexander C. Huang,Michael R. Betts,Nuala J. Meyer,E. John Wherry +34 more
TL;DR: Three “immunotypes” associated with poor clinical trajectories versus improving health are identified and may have implications for therapeutics and vaccines.
Journal ArticleDOI
Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States.
George L. Anesi,Juliane Jablonski,Michael O. Harhay,Joshua H. Atkins,Jasmeet Bajaj,Cameron Baston,Patrick J. Brennan,Christina Candeloro,Lauren M Catalano,Maurizio Cereda,John M. Chandler,Jason D. Christie,Tara Collins,Katherine R. Courtright,Barry D. Fuchs,Emily K. Gordon,John C. Greenwood,Steven W Gudowski,Asaf Hanish,C. William Hanson,Monica Heuer,Paul Kinniry,Zev Noah Kornfield,Gregory B. Kruse,Meghan B. Lane-Fall,Niels D. Martin,Mark E. Mikkelsen,Dan Negoianu,Jose L. Pascual,Maulik B Patel,Steven C. Pugliese,Zaffer Qasim,John P. Reilly,John Salmon,William D. Schweickert,Michael J. Scott,Michael G.S. Shashaty,Corinna Sicoutris,John K Wang,Wei Wang,Arshad A Wani,Brian J. Anderson,Jacob T. Gutsche +42 more
TL;DR: In this article, the authors describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery, in a single-health system, multihospital retrospective cohort study.
Journal ArticleDOI
Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis
John P. Reilly,Fan Wang,Tiffanie K. Jones,Jessica A. Palakshappa,Brian J. Anderson,Michael G.S. Shashaty,Thomas G. Dunn,Erik Johansson,Thomas Riley,Brian Lim,Jason Abbott,Caroline A. G. Ittner,Edward Cantu,Xihong Lin,Carmen Mikacenic,Mark M. Wurfel,David C. Christiani,Carolyn S. Calfee,Michael A. Matthay,Jason D. Christie,Rui Feng,Nuala J. Meyer +21 more
TL;DR: In septic European ancestry subjects, the strongest ANG2-determining ANGPT2 genetic variant is associated with higher ARDS risk, suggesting plasma ANG2 may be a causal factor in ARDS development.