R
R.S. Agyekum
Researcher at University of Pennsylvania
Publications - 20
Citations - 1013
R.S. Agyekum is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 5 publications receiving 472 citations.
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Journal ArticleDOI
Comprehensive mapping of immune perturbations associated with severe COVID-19.
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,Oliva Kuthuru,Sokratis A. Apostolidis,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,E. John Wherry,Nuala J. Meyer,Michael R. Betts +33 more
TL;DR: The neutrophil to lymphocyte ratio is found to be a prognostic biomarker of disease severity and organ failure and broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
Journal ArticleDOI
CD8 + T cells contribute to survival in patients with COVID-19 and hematologic cancer.
Erin Bange,Nicholas Han,Paul Wileyto,Justin Kim,Sigrid Gouma,James Robinson,Allison R. Greenplate,Madeline A Hwee,Florence Porterfield,Olutosin Owoyemi,Karan Naik,Cathy Zheng,Michael Galantino,Ariel R. Weisman,Caroline A. G. Ittner,Emily M. Kugler,Amy E. Baxter,Olutwatosin Oniyide,R.S. Agyekum,Thomas G. Dunn,Tiffanie K. Jones,Heather M. Giannini,Madison E. Weirick,Christopher M McAllister,N. Esther Babady,Anita Kumar,Adam J Widman,Susan DeWolf,Sawsan R. Boutemine,Charlotte Roberts,Krista R Budzik,Susan Tollett,Carla Wright,Tara Perloff,Lova Sun,Divij Mathew,Josephine R. Giles,Derek A. Oldridge,Jennifer E. Wu,Cécile Alanio,Sharon Adamski,Alfred L. Garfall,Laura A. Vella,Samuel J Kerr,Samuel J Kerr,Justine V. Cohen,Randall A. Oyer,Randall A. Oyer,Ryan Massa,Ivan Maillard,Kara N. Maxwell,John P. Reilly,Peter Maslak,Robert H. Vonderheide,Jedd D. Wolchok,Scott E. Hensley,E. John Wherry,Nuala J. Meyer,Angela DeMichele,Santosha Vardhana,Ronac Mamtani,Alexander C. Huang +61 more
TL;DR: In this paper, the authors showed that CD8 T cell responses to vaccination might provide protection in patients with hematologic cancer even in the setting of limited humoral responses, including those treated with anti-CD20 therapy.
Posted ContentDOI
Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Olivia Kuthuru,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,Nuala J. Meyer,Michael R. Betts +29 more
TL;DR: Broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation are demonstrated.
Posted ContentDOI
CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer
Alexander C. Huang,Erin Bange,Nicholas Han,E. P. Wileyto,Justin Kim,Sigrid Gouma,James Robinson,Allison R. Greenplate,Florence Porterfield,Olutosin Owoyemi,K. Naik,Cathy Zheng,M. Galantino,Ariel R. Weisman,Caroline A. G. Ittner,Emily M. Kugler,Amy E. Baxter,Madison E. Weirick,Christopher M McAllister,N. E. Babady,Anita Kumar,Adam J Widman,Susan DeWolf,Sawsan R. Boutemine,C. Roberts,K. Budzik,S. Tollett,C. Wright,T. Perloff,Lova Sun,Divij Mathew,Josephine R. Giles,Derek A. Oldridge,Jennifer E. Wu,Cécile Alanio,Sharon Adamski,Laura A. Vella,S. Kerr,Justine V. Cohen,Randall A. Oyer,Ryan Massa,Ivan Maillard,Kara N. Maxwell,Peter Maslak,Robert H. Vonderheide,Jedd D. Wolchok,Scott E. Hensley,E. Wherry,Nuala J. Meyer,Angela DeMichele,Santosha Vardhana,Ronac Mamtani,Oluwatosin Oniyide,R.S. Agyekum,Thomas G. Dunn,Tiffanie K. Jones,Heather M. Giannini,Alfred L. Garfall,John P. Reilly +58 more
TL;DR: In this article, the authors found that patients with hematologic cancers had a significantly higher mortality relative to patients with solid cancers after accounting for confounders including ECOG performance status and active cancer status.
Journal ArticleDOI
Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study
Todd A. Miano,Sean Hennessy,Wei Yang,Thomas G. Dunn,Ariel R. Weisman,Oluwatosin Oniyide,R.S. Agyekum,Alexandra P. Turner,Caroline A. G. Ittner,Brian J. Anderson,F. F. Wilson,Raymond R. Townsend,John P. Reilly,Heather M. Giannini,Christopher V. Cosgriff,Tiffanie K. Jones,Nuala J. Meyer,Michael G.S. Shashaty +17 more
TL;DR: Vancomycin + piperacillin-tazobactam was associated with increased acute kidney injury (AKI) risk as mentioned in this paper , but it is unclear whether the association represents true injury or a pseudotoxicity characterized by isolated effects on creatinine secretion.