Z
Zeyu Chen
Researcher at University of Pennsylvania
Publications - 24
Citations - 4970
Zeyu Chen is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 14, co-authored 24 publications receiving 2763 citations. Previous affiliations of Zeyu Chen include Peking University.
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Journal ArticleDOI
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Divij Mathew,Josephine R. Giles,Amy E. Baxter,Derek A. Oldridge,Allison R. Greenplate,Jennifer E. Wu,Cécile Alanio,Leticia Kuri-Cervantes,M. Betina Pampena,Kurt D'Andrea,Sasikanth Manne,Zeyu Chen,Yinghui Jane Huang,John P. Reilly,Ariel R. Weisman,Caroline A. G. Ittner,Oliva Kuthuru,Jeanette Dougherty,Kito Nzingha,Nicholas Han,Justin Kim,Ajinkya Pattekar,Eileen C. Goodwin,Elizabeth M. Anderson,Madison E. Weirick,Sigrid Gouma,Claudia P. Arevalo,Marcus J. Bolton,Fang Chen,Simon F. Lacey,Holly Ramage,Sara Cherry,Scott E. Hensley,Sokratis A. Apostolidis,Alexander C. Huang,Laura A. Vella,Laura A. Vella,Michael R. Betts,Nuala J. Meyer,E. John Wherry +39 more
TL;DR: High-dimensional flow cytometry of hospitalized COVID-19 patients found three prominent and distinct immunotypes that are related to disease severity and clinical parameters, and a compendium of immune cell information and roadmaps for potential therapeutic interventions is provided.
Journal ArticleDOI
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Kristen E. Pauken,Morgan A. Sammons,Pamela M. Odorizzi,Sasikanth Manne,Jernej Godec,Omar Khan,Adam M. Drake,Zeyu Chen,Debattama R. Sen,Makoto Kurachi,R. Anthony Barnitz,Caroline Bartman,Bertram Bengsch,Alexander C. Huang,Jason M. Schenkel,Golnaz Vahedi,W. Nicholas Haining,W. Nicholas Haining,Shelley L. Berger,E. John Wherry +19 more
TL;DR: The data indicate that epigenetic fate inflexibility may limit current immunotherapies, and PD-1 pathway blockade resulted in transcriptional rewiring and reengagement of effector circuitry in the TEX epigenetic landscape.
Journal ArticleDOI
T cell responses in patients with COVID-19.
Zeyu Chen,E. John Wherry +1 more
TL;DR: Early reports of the T cell responses observed in patients with COVID-19 are summarized, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.
Journal ArticleDOI
Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy
Jinyang Li,Katelyn T. Byrne,Fangxue Yan,Taiji Yamazoe,Zeyu Chen,Timour Baslan,Lee P. Richman,Jeffrey H. Lin,Yu H. Sun,Andrew J. Rech,David Balli,Ceire A. Hay,Yogev Sela,Allyson J. Merrell,Shannon M. Liudahl,Naomi Gordon,Robert J. Norgard,Salina Yuan,Sixiang Yu,Timothy Chao,Shuai Ye,T.S. Karin Eisinger-Mathason,Robert B. Faryabi,John W. Tobias,Scott W. Lowe,Scott W. Lowe,Lisa M. Coussens,E. John Wherry,Robert H. Vonderheide,Ben Z. Stanger +29 more
TL;DR: A library of congenic tumor cell clones from an autochthonous mouse model of pancreatic adenocarcinoma is established, identifying heterogeneous and multifactorial pathways regulating tumor‐cell‐intrinsic mechanisms that dictate the immune microenvironment and thereby responses to immunotherapy.
Journal ArticleDOI
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Jean-Christophe Beltra,Sasikanth Manne,Mohamed S. Abdel-Hakeem,Makoto Kurachi,Josephine R. Giles,Zeyu Chen,Valentina Casella,Shin Foong Ngiow,Omar Khan,Yinghui Jane Huang,Patrick Yan,Kito Nzingha,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Alexander C. Huang,E. John Wherry +19 more
TL;DR: A four-cell-stage developmental framework for Tex cells is defined and the control mechanisms underlying subset transitions are identified and a key interplay between TCF1, T-bet, and Tox is defined in the process.