S
Santosha Vardhana
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 24
Citations - 1422
Santosha Vardhana is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 10, co-authored 24 publications receiving 681 citations.
Papers
More filters
Journal ArticleDOI
The many faces of the anti-COVID immune response.
TL;DR: This Perspective explores the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offers suggestions to both understand and therapeutically modulate anti-COVID immunity.
Journal ArticleDOI
CD8 + T cells contribute to survival in patients with COVID-19 and hematologic cancer.
Erin Bange,Nicholas Han,Paul Wileyto,Justin Kim,Sigrid Gouma,James Robinson,Allison R. Greenplate,Madeline A Hwee,Florence Porterfield,Olutosin Owoyemi,Karan Naik,Cathy Zheng,Michael Galantino,Ariel R. Weisman,Caroline A. G. Ittner,Emily M. Kugler,Amy E. Baxter,Olutwatosin Oniyide,R.S. Agyekum,Thomas G. Dunn,Tiffanie K. Jones,Heather M. Giannini,Madison E. Weirick,Christopher M McAllister,N. Esther Babady,Anita Kumar,Adam J Widman,Susan DeWolf,Sawsan R. Boutemine,Charlotte Roberts,Krista R Budzik,Susan Tollett,Carla Wright,Tara Perloff,Lova Sun,Divij Mathew,Josephine R. Giles,Derek A. Oldridge,Jennifer E. Wu,Cécile Alanio,Sharon Adamski,Alfred L. Garfall,Laura A. Vella,Samuel J Kerr,Samuel J Kerr,Justine V. Cohen,Randall A. Oyer,Randall A. Oyer,Ryan Massa,Ivan Maillard,Kara N. Maxwell,John P. Reilly,Peter Maslak,Robert H. Vonderheide,Jedd D. Wolchok,Scott E. Hensley,E. John Wherry,Nuala J. Meyer,Angela DeMichele,Santosha Vardhana,Ronac Mamtani,Alexander C. Huang +61 more
TL;DR: In this paper, the authors showed that CD8 T cell responses to vaccination might provide protection in patients with hematologic cancer even in the setting of limited humoral responses, including those treated with anti-CD20 therapy.
Journal ArticleDOI
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.
Santosha Vardhana,Madeline A. Hwee,Mirela Berisa,Daniel K. Wells,Kathryn E. Yost,Bryan King,Melody Smith,Pamela S. Herrera,Pamela S. Herrera,Howard Y. Chang,Ansuman T. Satpathy,Marcel R.M. van den Brink,Justin R. Cross,Craig B. Thompson +13 more
TL;DR: It is revealed that loss of ATP production through oxidative phosphorylation limits T cell proliferation and effector function during chronic antigenic stimulation, and treatments that maintain redox balance promote T cell self-renewal and enhance anti-tumor immunity.
Journal ArticleDOI
Cancer Metabolism Drives a Stromal Regenerative Response.
TL;DR: It is proposed that metabolites consumed and released by tumor cells act as paracrine factors that regulate the non-malignant cellular composition of a developing tumor by driving stromal cells toward a regenerative response that supports tumor growth.
Journal ArticleDOI
The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints.
Santosha Vardhana,Anas Younes +1 more
TL;DR: This review summarizes what is known regarding T cells, B cells, and immune checkpoints in classical Hodgkin lymphoma to help clarify the role of the immune microenvironment in either promoting or restricting Classical Hodgkins lymphoma growth.